{"id":"W4296224660","doi":"10.1093/ecco-jcc/jjx021","title":"Exposure–efficacy Relationships for Vedolizumab Induction Therapy in Patients with Ulcerative Colitis or Crohn’s Disease","year":2017,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Western University","funders":"Takeda Development Center Americas","keywords":"Vedolizumab; Medicine; Ulcerative colitis; Internal medicine; Gastroenterology; Calprotectin; Faecal calprotectin; Logistic regression; Crohn's disease; Inflammatory bowel disease; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001970875,0.0001265015,0.0001575839,0.00005498842,0.0003365309,0.0001278809,0.0001319109,0.00008400478,0.0000152004],"category_scores_gemma":[0.0003116608,0.00009572724,0.00006787778,0.00002183489,0.0001201111,0.00004426738,0.00002621626,0.0001171741,4.831172e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003243059,"about_ca_system_score_gemma":0.0002780014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006811281,"about_ca_topic_score_gemma":0.0001490278,"domain_scores_codex":[0.9991412,0.00009312705,0.0002852668,0.0001602671,0.0001468337,0.0001733078],"domain_scores_gemma":[0.9988196,0.00002228983,0.0003744073,0.000229372,0.0003714461,0.0001828304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2986624,0.0008384997,0.6442119,0.00009013562,0.0002714324,0.0006902838,0.0006546373,0.00006082962,0.00004450442,0.0009509629,0.002040348,0.05148403],"study_design_scores_gemma":[0.006517473,0.0007653366,0.9896913,0.00006821198,0.00002596496,0.00001018713,0.00007202604,0.000004681571,0.0001002805,0.0002491528,0.002357887,0.0001375504],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989077,0.00008420683,0.0000907773,0.0001413817,0.0001394268,0.0004600557,0.00008963178,0.000002071175,0.00008470114],"genre_scores_gemma":[0.999046,0.0001340407,0.00017734,0.00007272901,0.0002790852,0.00003231073,0.00002567207,0.00001799749,0.0002148739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3454793,"threshold_uncertainty_score":0.3903643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02105818360127284,"score_gpt":0.2669874869363316,"score_spread":0.2459293033350587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}