{"id":"W4296230849","doi":"10.1158/1557-3265.sarcomas22-a012","title":"Abstract A012: Targeting the dysregulation of transcription and splicing in Ewing sarcoma","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"FLI1; RNA splicing; Sarcoma; Cancer research; Biology; Pediatric cancer; Transcription (linguistics); Alternative splicing; Transcription factor; RNA polymerase II; RNA; Medicine; Cancer; Genetics; Gene expression; Messenger RNA; Gene; Promoter; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002124317,0.0004880106,0.0003588146,0.0002876044,0.0001773556,0.0004144757,0.0003367476,0.0003850556,0.002600759],"category_scores_gemma":[0.0001172363,0.0001891084,0.0003647741,0.0002232122,0.0002383537,0.0002548062,0.0002219158,0.0009146925,0.0008084205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000364236,"about_ca_system_score_gemma":0.0003137336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005147986,"about_ca_topic_score_gemma":0.0007147633,"domain_scores_codex":[0.9997991,0.00002077795,0.00002746336,0.0000527422,0.00007457368,0.00002539912],"domain_scores_gemma":[0.9999069,0.00001692703,0.00002652427,0.00001116845,0.00001450834,0.00002387322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004797326,0.00002660589,0.00007864917,0.00003809603,0.000003668714,0.00003292616,0.00000463707,0.00006305954,0.9980645,0.0001241382,0.00008129564,0.001434516],"study_design_scores_gemma":[0.00002535257,0.0003202865,0.0008870894,0.000006548411,0.00002343359,0.0002129891,0.00001295346,0.0009313677,0.9927658,0.0000708705,0.004738702,0.000004624966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9582492,0.007154245,0.02243245,0.0006989077,0.0003576561,0.0002957684,0.0029495,0.001077812,0.006784503],"genre_scores_gemma":[0.9717568,0.003221842,0.01131104,0.0002397289,0.00004193343,0.0001306128,0.003094039,0.0001210707,0.01008288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002600759,"threshold_uncertainty_score":0.00870043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2455350743998398,"score_gpt":0.5033545763057851,"score_spread":0.2578195019059452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}