{"id":"W4296236117","doi":"10.1021/acschembio.2c00451","title":"Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes","year":2022,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; Ontario Institute for Cancer Research; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Epigenetics; Cytotoxicity; Biology; Drug discovery; Chemistry; ATP-binding cassette transporter; Abcg2; Pharmacology; Biochemistry; Transporter; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001827895,0.0001837817,0.0002897028,0.00004480584,0.0000756853,0.000007755556,0.0004290003,0.000166775,0.00008892442],"category_scores_gemma":[0.0003395882,0.0001785233,0.0001275121,0.0001403054,0.0003136277,0.000003838751,0.0006008709,0.0002027277,0.000005817347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000269628,"about_ca_system_score_gemma":0.00007882184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000236832,"about_ca_topic_score_gemma":6.67702e-7,"domain_scores_codex":[0.9985892,0.0001493311,0.0003397648,0.0004504967,0.00016312,0.0003080744],"domain_scores_gemma":[0.9992833,0.0000651394,0.0001464957,0.0003469352,0.00007481699,0.00008338311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001387327,0.000162357,0.001336515,0.0000368034,0.0000594284,0.000001455569,0.00002599751,0.000001323045,0.9925026,0.0008547106,0.00391206,0.0009679678],"study_design_scores_gemma":[0.000957025,0.0002115611,0.0000842483,0.000007510432,0.0000196745,0.000005880371,0.00001916313,0.000009228164,0.9779779,0.002864633,0.01764135,0.0002018411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960176,0.002207869,0.00009068866,0.0002505924,0.0006701585,0.0003477515,0.00005223903,0.00002192555,0.0003411264],"genre_scores_gemma":[0.9981983,0.00009734726,0.0002540285,0.0002541286,0.0003363303,0.0001370846,0.0005793257,0.00002183695,0.0001215784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01452476,"threshold_uncertainty_score":0.7279967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004135220190806531,"score_gpt":0.229685127538645,"score_spread":0.2255499073478384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}