{"id":"W4296236117","doi":"10.1021/acschembio.2c00451","title":"Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes","year":2022,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; Ontario Institute for Cancer Research; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Epigenetics; Cytotoxicity; Biology; Drug discovery; Chemistry; ATP-binding cassette transporter; Abcg2; Pharmacology; Biochemistry; Transporter; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002754429,0.000529994,0.00073073,0.0006547244,0.0001295256,0.0003541633,0.0003845785,0.0003939429,0.001807805],"category_scores_gemma":[0.0002811495,0.000211866,0.0003540092,0.000424531,0.0001896281,0.0002140083,0.0003049413,0.0004598833,0.0003728587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003629096,"about_ca_system_score_gemma":0.000216282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002659654,"about_ca_topic_score_gemma":0.001160092,"domain_scores_codex":[0.9997019,0.00004277945,0.00002363865,0.0000640634,0.0001217673,0.00004579448],"domain_scores_gemma":[0.9998378,0.00004185828,0.00003579861,0.00002453455,0.00003283327,0.00002732838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001424727,0.0001970913,0.0005186927,0.00009406434,0.00003813479,0.00007953894,0.00001025641,0.0008712527,0.9871613,0.0001533125,0.0001216003,0.01061218],"study_design_scores_gemma":[0.00005681732,0.001820242,0.002335634,0.000005421931,0.00007280142,0.0001859612,0.00001169743,0.002059045,0.9910025,0.0000435197,0.002396631,0.000009705319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744753,0.003657122,0.01396525,0.0001393977,0.00004944573,0.0005569381,0.001128949,0.00040962,0.005617944],"genre_scores_gemma":[0.9837003,0.002069459,0.009924612,0.0001511716,0.00001444893,0.0002674234,0.001186684,0.00004128194,0.002644593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001807805,"threshold_uncertainty_score":0.006047726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004135220190806531,"score_gpt":0.229685127538645,"score_spread":0.2255499073478384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}