{"id":"W4296246565","doi":"10.3390/pharmaceutics14091917","title":"Simultaneous Imaging and Therapy Using Epitope-Specific Anti-Epidermal Growth Factor Receptor (EGFR) Antibody Conjugates","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal University Hospital; University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Nimotuzumab; Monoclonal antibody; Epitope; Epidermal growth factor receptor; Biodistribution; Conjugate; Chemistry; Antibody; Cancer research; Antibody-drug conjugate; Pharmacology; Immunohistochemistry; Molecular biology; Receptor; Medicine; In vitro; Immunology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002223841,0.0003536786,0.0005360015,0.0002235545,0.00009025681,0.0003539021,0.000380978,0.0004524381,0.0004970384],"category_scores_gemma":[0.0001245356,0.0001995818,0.0002891369,0.0002277797,0.0001509816,0.0002673989,0.0002589273,0.0003728056,0.0001789312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000504682,"about_ca_system_score_gemma":0.0001835825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000694146,"about_ca_topic_score_gemma":0.001160142,"domain_scores_codex":[0.9997724,0.00003696333,0.00001030536,0.00007393479,0.00006932336,0.00003717983],"domain_scores_gemma":[0.9999548,0.000007581127,0.00001576149,0.000005868658,0.000006625904,0.000009276028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001136538,0.00002857662,0.0001800028,0.0000330837,0.000008937392,0.00004321212,0.000009241617,0.0002145461,0.9965778,0.00005484887,0.00005230298,0.002683757],"study_design_scores_gemma":[0.00002248819,0.0003001226,0.001464383,0.000002078048,0.0000207888,0.0002581245,0.000006388886,0.002807657,0.9933524,0.00001909525,0.00174179,0.000004646081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.957324,0.004706997,0.03458006,0.0001404117,0.00004229818,0.0001352038,0.0002597877,0.0002644693,0.002546735],"genre_scores_gemma":[0.9701511,0.001717953,0.02459808,0.00007766419,0.00001672991,0.0001312833,0.0003315401,0.00003738025,0.002938221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000694146,"threshold_uncertainty_score":0.003661752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1159825200060079,"score_gpt":0.429537386902816,"score_spread":0.313554866896808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}