{"id":"W4296251996","doi":"10.1101/2022.09.17.508236","title":"Thermophilic carboxylesterases from hydrothermal vents of the volcanic island of Ischia active on synthetic and biobased polymers and mycotoxins","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"Agencia Estatal de Investigación; European Regional Development Fund; Natural Environment Research Council; Sight Research UK; Ministerio de Ciencia e Innovación; European Commission; Ministerio de Economía y Competitividad; Llywodraeth Cymru","keywords":"Thermophile; Thermostability; Catalytic triad; Hydrolase; Hydrothermal vent; Biology; Active site; Chemistry; Enzyme; Biochemistry; Microbiology; Hydrothermal circulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000124102,0.000269268,0.0003235923,0.00007511172,0.00007895681,0.00001962638,0.0002660276,0.000204049,0.00004221631],"category_scores_gemma":[0.00007889355,0.0002278659,0.0001111906,0.0001281602,0.0001647405,0.000005221032,0.0004239149,0.0001936492,3.077057e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002765524,"about_ca_system_score_gemma":0.0001615438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000130211,"about_ca_topic_score_gemma":0.00001894319,"domain_scores_codex":[0.9986488,0.0001642512,0.0002851434,0.0005565265,0.0001879104,0.0001573461],"domain_scores_gemma":[0.9986522,0.00002948814,0.0003888406,0.0007974788,0.00007102393,0.00006100063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009383757,0.00009510888,0.008469719,0.00008612639,0.0001881541,8.525485e-7,0.00001874122,0.00005210573,0.9909557,0.00002405164,0.000009959825,0.000005701574],"study_design_scores_gemma":[0.0003628159,0.000124953,0.109944,0.0001449524,0.0001263091,1.144262e-8,0.00001107093,0.00007254038,0.8887746,8.132783e-7,0.0002308328,0.000207067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956934,0.002455294,0.00001595043,0.00003191443,0.0001939537,0.0003953938,0.001197529,0.000008083516,0.000008420248],"genre_scores_gemma":[0.9993045,0.0004145642,0.0000213915,0.0000790733,0.0000658518,0.00005506527,0.000004652683,0.00005011961,0.000004783536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.102181,"threshold_uncertainty_score":0.9292099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006209691173239344,"score_gpt":0.1981970385668346,"score_spread":0.1919873473935952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}