{"id":"W4296253011","doi":"10.3390/curroncol29090520","title":"Acquired G2032R Resistance Mutation in ROS1 to Lorlatinib Therapy Detected with Liquid Biopsy","year":2022,"lang":"en","type":"article","venue":"Current Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"ROS1; Anaplastic lymphoma kinase; Medicine; Cancer research; Context (archaeology); Mutation; Tyrosine kinase; Lung cancer; Crizotinib; Tyrosine-kinase inhibitor; Targeted therapy; Internal medicine; Cancer; Gene; Adenocarcinoma; Receptor; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001182345,0.0003697828,0.0003449252,0.0004972377,0.0002971086,0.0004998978,0.0002670063,0.0008714508,0.001642195],"category_scores_gemma":[0.0005292978,0.0001384483,0.0002892527,0.0001841942,0.0002816434,0.0003336984,0.0002508245,0.0007239987,0.0005030761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004001994,"about_ca_system_score_gemma":0.0002147376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00123659,"about_ca_topic_score_gemma":0.001638013,"domain_scores_codex":[0.9998436,0.00001552802,0.00001464445,0.00005194109,0.00003326342,0.00004102128],"domain_scores_gemma":[0.9997889,0.00005323508,0.00004899033,0.00001452576,0.00003254881,0.00006181699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.001474833,0.0003236966,0.1082112,0.0001598617,0.00005134808,0.661404,0.0005298944,0.0004500504,0.1968001,0.0003814145,0.001140248,0.0290734],"study_design_scores_gemma":[0.00006340088,0.001974759,0.0941082,0.00005692548,0.000134224,0.813919,0.0003859572,0.004384323,0.07976499,0.0003104318,0.004863964,0.00003377249],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922721,0.0009484426,0.001321467,0.000619443,0.00004293918,0.00006757471,0.0002673986,0.00008502202,0.004375542],"genre_scores_gemma":[0.9979295,0.000287664,0.0004821878,0.0001993426,0.00002329413,0.000006165863,0.00015415,0.00000902727,0.0009087744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001642195,"threshold_uncertainty_score":0.005493701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05855500493016243,"score_gpt":0.4190327583631759,"score_spread":0.3604777534330135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}