{"id":"W4296299315","doi":"10.26685/urncst.395","title":"Effects of Procainamide on CTLA-4 and CD28 Expression in Drug-Induced Lupus: A Research Protocol","year":2022,"lang":"en","type":"article","venue":"Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Queen's University","funders":"University of Ottawa","keywords":"CD28; Procainamide; Systemic lupus erythematosus; CTLA-4; Immunology; Antigen; Biology; Medicine; Molecular biology; Chemistry; Cancer research; T cell; Internal medicine; Immune system; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002401273,0.001256613,0.001851958,0.0008613167,0.0009701378,0.0009224873,0.001211897,0.00147212,0.01821123],"category_scores_gemma":[0.001026426,0.0005570318,0.002045545,0.0007464845,0.0005567285,0.000520549,0.0006620826,0.002056862,0.003741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006016117,"about_ca_system_score_gemma":0.00194725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005323292,"about_ca_topic_score_gemma":0.001171453,"domain_scores_codex":[0.9989022,0.0002404111,0.000130962,0.0002893759,0.000258886,0.0001781087],"domain_scores_gemma":[0.9988469,0.0002213905,0.000152319,0.0002101445,0.0003920103,0.0001772396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0194684,0.008561647,0.001206311,0.007293652,0.0002801192,0.0005667785,0.0002500598,0.001147783,0.9056121,0.001866615,0.0098603,0.04388623],"study_design_scores_gemma":[0.007649385,0.09118245,0.008292242,0.0009654672,0.001860062,0.001079166,0.0003201005,0.001349964,0.6724559,0.001482036,0.2131283,0.000234877],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.5856264,0.04222155,0.1048109,0.003078695,0.005587848,0.1826342,0.03899044,0.002316684,0.03473336],"genre_scores_gemma":[0.3446203,0.04744102,0.1125729,0.004180631,0.001267003,0.3700346,0.04065462,0.0004461535,0.07878274],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01821123,"threshold_uncertainty_score":0.06092256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04825277533932658,"score_gpt":0.4195946485144381,"score_spread":0.3713418731751115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}