{"id":"W4296301869","doi":"10.1101/2022.09.15.508143","title":"Systemic and intrinsic functions of ATRX in glial cell fate and CNS myelination","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"","keywords":"ATRX; OLIG2; Oligodendrocyte; Biology; Neuroscience; Myelin; Cell biology; Genetics; Gene; Central nervous system; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001508924,0.0003348333,0.0002197702,0.0002257288,0.0001407954,0.0003018271,0.0002315797,0.0002499212,0.001220171],"category_scores_gemma":[0.000111086,0.0001268144,0.0002174776,0.00009292839,0.0003604019,0.000240874,0.0004032312,0.0004361485,0.0002845752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002052044,"about_ca_system_score_gemma":0.0001935141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002452217,"about_ca_topic_score_gemma":0.0003979899,"domain_scores_codex":[0.9998513,0.00001761758,0.00001719406,0.00004562824,0.0000424707,0.00002578498],"domain_scores_gemma":[0.9998535,0.00001628456,0.0000581268,0.00002252464,0.00001444956,0.000035076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005209008,0.000006335517,0.001102513,0.00003586875,0.000008111801,0.0001363292,0.00001500044,0.00008721466,0.9967707,0.0002997975,0.0000141996,0.001471954],"study_design_scores_gemma":[0.00001017737,0.0001752848,0.02772997,0.00001741879,0.00005881483,0.001428513,0.00008118156,0.001046973,0.9669574,0.000366857,0.002122374,0.00000504587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900445,0.003529482,0.004258834,0.00008645694,0.00001705397,0.000007169757,0.0002775888,0.00006859079,0.001710419],"genre_scores_gemma":[0.9960237,0.001161608,0.0009318061,0.00002030122,0.000007713952,0.000008664828,0.0001712794,0.00001910435,0.001655865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001220171,"threshold_uncertainty_score":0.004081845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007062581062859585,"score_gpt":0.1942219649636662,"score_spread":0.1871593839008066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}