{"id":"W4296301883","doi":"10.1101/2022.09.19.508447","title":"Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 using Proximity Labeling and Affinity Purification","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children; Ontario Genomics; Genome Canada","keywords":"Interactome; Homologous recombination; Biology; Scaffold protein; Chromatin; DNA repair; Computational biology; Genetics; DNA; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001960575,0.0005861231,0.0003639552,0.001244138,0.0004808178,0.0003537359,0.0002918766,0.0003027817,0.00268398],"category_scores_gemma":[0.0002338828,0.0001722694,0.0004072729,0.0006762861,0.0001702903,0.0002191023,0.0005056387,0.0003150933,0.001026304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004116267,"about_ca_system_score_gemma":0.0003142827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001579409,"about_ca_topic_score_gemma":0.003042727,"domain_scores_codex":[0.9997743,0.00002104583,0.00001019002,0.00007458314,0.00008808363,0.00003193209],"domain_scores_gemma":[0.9999167,0.00002045076,0.00002174731,0.000008673231,0.00001551497,0.00001694726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008612283,0.00001130771,0.002295864,0.0001120307,0.00005614182,0.00009984717,0.00002309359,0.0001862486,0.9928489,0.0001153223,0.0002739793,0.003891095],"study_design_scores_gemma":[0.00003163464,0.0001711308,0.07976265,0.00003436733,0.000198179,0.001502025,0.0001389263,0.01153883,0.8859745,0.0005529435,0.02006223,0.00003259352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9398499,0.006857793,0.04173404,0.0003614151,0.00002677006,0.00009691696,0.00784367,0.0009121336,0.002317391],"genre_scores_gemma":[0.9322943,0.002576479,0.04163283,0.0001647465,0.00002025938,0.0001374166,0.01661908,0.0001013883,0.006453408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00268398,"threshold_uncertainty_score":0.008978784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02366831490425463,"score_gpt":0.2383757361444651,"score_spread":0.2147074212402105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}