{"id":"W4296312509","doi":"10.3390/cells11182904","title":"Gene Profiling of a 3D Psoriatic Skin Model Enriched in T Cells: Downregulation of PTPRM Promotes Keratinocyte Proliferation through Excessive ERK1/2 Signaling","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval; Centre hospitalier de l'Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Psoriasis; Dermis; Keratinocyte; Effector; Pathogenesis; Epidermis (zoology); Biology; Immune system; Downregulation and upregulation; Signal transduction; Cell biology; Immunology; Cancer research; Gene; Genetics; Cell culture; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116626,0.0002537455,0.0002528008,0.0002701457,0.0001142756,0.0002004646,0.00009614448,0.0002276664,0.0006540118],"category_scores_gemma":[0.00006077507,0.0001062704,0.0002898852,0.0002470154,0.0001456413,0.00009283717,0.0001132595,0.0003699143,0.0002156704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009218154,"about_ca_system_score_gemma":0.00009789615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003932962,"about_ca_topic_score_gemma":0.0005307692,"domain_scores_codex":[0.9998586,0.00001896845,0.00001043096,0.00003085941,0.00005373121,0.00002731308],"domain_scores_gemma":[0.999928,0.00001557973,0.00001598236,0.000008575962,0.00001376557,0.00001814323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005488252,0.00001269606,0.00006783559,0.000008494921,0.000001619371,0.00002057712,0.000007745564,0.00003351678,0.9995829,0.000008403386,0.000005898373,0.0001952199],"study_design_scores_gemma":[0.000008624032,0.0002580067,0.005876163,0.000002635851,0.0000207464,0.0001531023,0.00004604806,0.001664396,0.9914476,0.00001984847,0.0004967144,0.000006145176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922293,0.0004186096,0.006011929,0.00003853196,0.00002592307,0.00003476872,0.0005465615,0.00006258913,0.0006319252],"genre_scores_gemma":[0.988388,0.0005455614,0.00835795,0.00007774676,0.000008938801,0.00009715389,0.0007452131,0.00002606764,0.001753354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006540118,"threshold_uncertainty_score":0.002187908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068660706961135,"score_gpt":0.2386810851954511,"score_spread":0.2179944781258398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}