{"id":"W4296312509","doi":"10.3390/cells11182904","title":"Gene Profiling of a 3D Psoriatic Skin Model Enriched in T Cells: Downregulation of PTPRM Promotes Keratinocyte Proliferation through Excessive ERK1/2 Signaling","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval; Centre hospitalier de l'Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Psoriasis; Dermis; Keratinocyte; Effector; Pathogenesis; Epidermis (zoology); Biology; Immune system; Downregulation and upregulation; Signal transduction; Cell biology; Immunology; Cancer research; Gene; Genetics; Cell culture; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003407667,0.0001880761,0.0003884589,0.0001401573,0.000144435,0.000007062034,0.0001499384,0.0001386266,0.000154697],"category_scores_gemma":[0.00001914102,0.0001814297,0.00008623005,0.0002796548,0.00005262601,0.0001228102,0.00007429669,0.0001461754,0.000009341506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000818175,"about_ca_system_score_gemma":0.0001393487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004738021,"about_ca_topic_score_gemma":0.000007973847,"domain_scores_codex":[0.9984382,0.0003495002,0.0005731182,0.0003173986,0.0000859331,0.0002358686],"domain_scores_gemma":[0.9991339,0.0001161514,0.000426173,0.000226524,0.00008668897,0.00001049988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002459242,0.0003404078,0.0003386417,0.0000879147,0.000108148,0.000002318124,0.004754393,0.05338013,0.9381076,0.0001399103,0.00001490629,0.002479712],"study_design_scores_gemma":[0.001747005,0.0002112743,0.0002616408,0.00002421584,0.0001147892,0.000003356212,0.0003387769,0.009363625,0.9871687,0.0005957002,0.0000113772,0.00015952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994846,0.001583136,0.002193091,0.00001549868,0.0002609712,0.0008386545,0.00008819662,0.00002398939,0.0001504634],"genre_scores_gemma":[0.9914792,0.0000408301,0.007566407,0.00001489524,0.00002906945,0.0002038467,0.0003351466,0.00001957427,0.0003110053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04906112,"threshold_uncertainty_score":0.739849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068660706961135,"score_gpt":0.2386810851954511,"score_spread":0.2179944781258398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}