{"id":"W4296323280","doi":"10.1021/acs.jmedchem.2c00509","title":"Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4","year":2022,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Chemistry; Ubiquitin ligase; Protein subunit; Small molecule; DNA ligase; Stereochemistry; In vitro; Ubiquitin; Molecule; Effector; Ubiquitin-Protein Ligases; Biochemistry; Biophysics; DNA; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001492818,0.0002552655,0.0002105301,0.0001491328,0.0001883968,0.0001780328,0.000243122,0.0002133419,0.001615114],"category_scores_gemma":[0.0001758339,0.0001261742,0.0001699926,0.0001698237,0.0001457677,0.00009921903,0.0001501406,0.0003408288,0.0003462658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004979038,"about_ca_system_score_gemma":0.0002118276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007568215,"about_ca_topic_score_gemma":0.001093444,"domain_scores_codex":[0.9999212,0.00001348742,0.000004148507,0.0000126507,0.00002920918,0.00001926967],"domain_scores_gemma":[0.9999628,0.000008668017,0.000007445644,0.000004702048,0.000006375184,0.00001013894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001214446,0.00003458908,0.000253342,0.00002609728,0.000008861845,0.00005432448,0.00001138751,0.0003142245,0.9962916,0.0001633887,0.00009993498,0.00262078],"study_design_scores_gemma":[0.00003058836,0.0002127713,0.001129635,0.000002404474,0.00001153906,0.0001177846,0.00001266994,0.001014029,0.9948927,0.00004405115,0.002528264,0.000003526975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909197,0.001570965,0.004671294,0.0001761319,0.00001545266,0.00004579246,0.0003156472,0.00009360728,0.002191362],"genre_scores_gemma":[0.9911102,0.0007018555,0.003446421,0.00005977166,0.000004906001,0.00004431905,0.0008617165,0.00001407978,0.003756698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001615114,"threshold_uncertainty_score":0.005403042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007524250234120082,"score_gpt":0.2212731610928235,"score_spread":0.2137489108587034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}