{"id":"W4296323280","doi":"10.1021/acs.jmedchem.2c00509","title":"Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4","year":2022,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Chemistry; Ubiquitin ligase; Protein subunit; Small molecule; DNA ligase; Stereochemistry; In vitro; Ubiquitin; Molecule; Effector; Ubiquitin-Protein Ligases; Biochemistry; Biophysics; DNA; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000206611,0.00008122327,0.0001441698,0.00002399153,0.0000745116,0.000006184671,0.0002006414,0.0000488347,0.00003730796],"category_scores_gemma":[0.00007819037,0.00005980248,0.00008478174,0.00007633844,0.0001270244,0.0000072153,0.0001168961,0.0001875365,1.901975e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001658415,"about_ca_system_score_gemma":0.0001074241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005851528,"about_ca_topic_score_gemma":5.486616e-7,"domain_scores_codex":[0.9991904,0.00004505173,0.0003397471,0.0000872369,0.0002588568,0.0000786463],"domain_scores_gemma":[0.9991519,0.000006081726,0.000560586,0.0001418887,0.00009377668,0.0000457745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007267894,0.00002468693,0.002431604,0.00006410869,0.00003289731,0.000002887758,0.00005582678,0.000007291736,0.9969779,0.000006109279,0.00009870749,0.0002252951],"study_design_scores_gemma":[0.0005914956,0.0001834793,0.005463862,0.00004312236,0.00003163192,0.0001326229,0.0002996762,0.00001671605,0.9927934,0.00002277943,0.0003635774,0.00005765589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999147,0.0002472245,0.00004770092,0.0002645806,0.00009175463,0.00005059075,0.00002060265,8.683327e-7,0.0001296933],"genre_scores_gemma":[0.9993176,0.00003727577,0.00001743307,0.00009319732,0.0001600741,0.000001464673,0.00003907594,0.000007593703,0.0003262212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004184525,"threshold_uncertainty_score":0.2438674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007524250234120082,"score_gpt":0.2212731610928235,"score_spread":0.2137489108587034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}