{"id":"W4296324589","doi":"10.1007/s00401-022-02491-8","title":"Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo","year":2022,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Montreal Neurological Institute and Hospital; McGill University; Douglas Mental Health University Institute; Western University","funders":"Common Fund; Institut de science ouverte Tanenbaum; NIH Office of the Director; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; Canada First Research Excellence Fund; Israel Science Foundation","keywords":"Phosphorylation; Dementia with Lewy bodies; Hsp90; Alpha-synuclein; Biology; PIN1; Cell biology; Synucleinopathies; Biochemistry; Chemistry; Heat shock protein; Parkinson's disease; Medicine; Internal medicine; Dementia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003435407,0.0001538717,0.0002608114,0.0000888387,0.0001822941,0.00001361102,0.000130845,0.00004398312,0.0003974759],"category_scores_gemma":[0.0002116951,0.0001061311,0.00006107365,0.0002842219,0.00007254572,0.00006119444,0.0002386135,0.000209991,0.000002095347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004188106,"about_ca_system_score_gemma":0.00003429877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005060282,"about_ca_topic_score_gemma":0.00000558614,"domain_scores_codex":[0.9986411,0.0002659847,0.0002357843,0.0003812449,0.0002680798,0.0002078097],"domain_scores_gemma":[0.9992592,0.0001137883,0.0001427036,0.0003881119,0.00002728462,0.00006885834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007467432,0.00119707,0.09587806,0.00005341013,0.00003190459,0.001227824,0.0004686475,0.0002331501,0.8927322,0.0002671889,0.0002038033,0.006960018],"study_design_scores_gemma":[0.001710439,0.001089951,0.5792985,0.00004055882,0.0001016536,0.000179872,0.0002508493,0.001236666,0.4131262,0.0009241237,0.001879766,0.0001614531],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976099,0.0002874294,0.00000354378,0.0007844642,0.00006554274,0.0005664221,0.00008735171,0.0000411628,0.0005542575],"genre_scores_gemma":[0.9991453,0.00007442508,0.0001450196,0.0003532041,0.00001821501,0.00008868581,0.00001457363,0.00001743933,0.0001431597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4834204,"threshold_uncertainty_score":0.4352083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03440323791420672,"score_gpt":0.2725245345335958,"score_spread":0.2381212966193891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}