{"id":"W4296328734","doi":"10.3233/jad-220808","title":"High Soluble Amyloid-β42 Predicts Normal Cognition in Amyloid-Positive Individuals with Alzheimer’s Disease-Causing Mutations","year":2022,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Korea Health Industry Development Institute; Japan Agency for Medical Research and Development; Fondation Brain Canada; Deutsches Zentrum für Neurodegenerative Erkrankungen; Fleni; Alzheimer's Association","keywords":"Dementia; PSEN1; Internal medicine; Pittsburgh compound B; Clinical Dementia Rating; Alzheimer's disease; Standardized uptake value; Cognitive decline; Oncology; Medicine; Poisson regression; Amyloid (mycology); Cerebrospinal fluid; Psychology; Pathology; Disease; Positron emission tomography; Amyloid precursor protein; Neuroscience; Population","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001293316,0.000511865,0.00031244,0.0007084173,0.0003399174,0.0005792986,0.0002801738,0.0005287381,0.00136565],"category_scores_gemma":[0.005099013,0.0003505784,0.0005683673,0.0004101649,0.00033985,0.0002778598,0.0002823523,0.0005238143,0.0002182677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001922161,"about_ca_system_score_gemma":0.0002060353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002910144,"about_ca_topic_score_gemma":0.002403395,"domain_scores_codex":[0.9996637,0.0001271401,0.00003267887,0.0000888558,0.0000511077,0.00003657096],"domain_scores_gemma":[0.9977766,0.0009399474,0.0007775794,0.0001378662,0.0001287644,0.0002392861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003661208,0.00004211757,0.9979603,0.000006320724,0.00008073076,0.0001151165,0.00003500581,0.0001182028,0.0002894316,0.00001208003,0.00004722638,0.0009273574],"study_design_scores_gemma":[0.00002357256,0.0001927298,0.9973977,0.000006710482,0.0001023595,0.000731089,0.00005666277,0.001153479,0.000151807,0.0000957422,0.00008326775,0.000004846908],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996638,0.0001069323,0.00005997298,0.0000154072,0.000003237134,0.000001969317,0.00003346347,0.000002738369,0.00011252],"genre_scores_gemma":[0.9997792,0.00003958034,0.00006094264,0.000005746153,0.00000515826,0.000001677679,0.0000567053,0.000001033517,0.00005005862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002910144,"threshold_uncertainty_score":0.006839812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02675038962181166,"score_gpt":0.3022355537251662,"score_spread":0.2754851641033546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}