{"id":"W4296329141","doi":"10.1371/journal.ppat.1010832","title":"Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Infectious Diseases Centre; Institute of Cancer Research; University of Saskatchewan; University of Calgary; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Research Nova Scotia; Canadian Institutes of Health Research; Dalhousie University; Innovation Saskatchewan","keywords":"GTPase; Biology; RHOA; Coronavirus; CDC42; RAC1; Viral entry; Virology; Subgenomic mRNA; Cell biology; Viral replication; Virus; Biochemistry; RNA; Gene; Coronavirus disease 2019 (COVID-19); Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002971429,0.0001683799,0.0001319333,0.0001030021,0.0005203814,0.00004674288,0.0001819831,0.00007200047,0.00005552141],"category_scores_gemma":[0.000048893,0.0001734078,0.00004671859,0.0002074512,0.00009599983,0.000008558921,0.000386633,0.0001844099,0.000009388674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004263559,"about_ca_system_score_gemma":0.0001983818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000114234,"about_ca_topic_score_gemma":0.0001563851,"domain_scores_codex":[0.9985831,0.0001713465,0.0002041872,0.0004493297,0.000327321,0.0002647281],"domain_scores_gemma":[0.999391,0.000004441178,0.00009925078,0.0003003375,0.0001038494,0.0001011638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004842078,0.0001752499,0.002635735,0.00004751041,0.00002574291,0.00001514817,0.0002074358,0.00004230754,0.9818395,0.00002534885,0.0000346515,0.0144672],"study_design_scores_gemma":[0.0005413478,0.002619261,0.0004941776,0.0000156873,0.00001931192,0.00002831891,0.000173842,0.0004008988,0.9903648,0.0004792148,0.004572891,0.0002902272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970499,0.001487575,0.00008365636,0.0002772844,0.00002394162,0.0008220694,0.00005639642,0.00003605316,0.0001631796],"genre_scores_gemma":[0.9972738,0.00004158439,0.0008702627,0.0002009134,0.0001414947,0.0007248569,0.0002082432,0.00004656159,0.0004922725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01417697,"threshold_uncertainty_score":0.7071365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02794242201201148,"score_gpt":0.2877062884297824,"score_spread":0.2597638664177709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}