{"id":"W4296329141","doi":"10.1371/journal.ppat.1010832","title":"Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Infectious Diseases Centre; Institute of Cancer Research; University of Saskatchewan; University of Calgary; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Research Nova Scotia; Canadian Institutes of Health Research; Dalhousie University; Innovation Saskatchewan","keywords":"GTPase; Biology; RHOA; Coronavirus; CDC42; RAC1; Viral entry; Virology; Subgenomic mRNA; Cell biology; Viral replication; Virus; Biochemistry; RNA; Gene; Coronavirus disease 2019 (COVID-19); Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007172101,0.0002530729,0.0001372003,0.0001163205,0.00008104087,0.0001569463,0.0001529718,0.0001858173,0.001276693],"category_scores_gemma":[0.000106549,0.00008125359,0.0001598459,0.00005167882,0.00009835137,0.0001184616,0.0001062526,0.0003823949,0.0003010018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008918036,"about_ca_system_score_gemma":0.00009824638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002928254,"about_ca_topic_score_gemma":0.0006717152,"domain_scores_codex":[0.999934,0.00001391862,0.000006119427,0.00001082975,0.00002200251,0.00001316155],"domain_scores_gemma":[0.9999179,0.00002019002,0.00002397762,0.00001280229,0.00001060702,0.00001452317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008450641,0.00004121331,0.0001210298,0.00003728016,0.00000839293,0.00002288011,0.000008482433,0.00006899061,0.9952515,0.00006520821,0.00003599495,0.004254517],"study_design_scores_gemma":[0.00001184314,0.0006670324,0.00184303,0.000004141059,0.000008203809,0.0001456189,0.000007261078,0.0005106196,0.9946062,0.00003926002,0.002154823,0.00000199382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893408,0.004819793,0.002837965,0.0001000926,0.00003672512,0.00003255226,0.0001547636,0.0001350204,0.002542416],"genre_scores_gemma":[0.9926197,0.00235354,0.001798521,0.00004729928,0.00001708518,0.0000250973,0.0002637865,0.00001834723,0.002856556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001276693,"threshold_uncertainty_score":0.004270971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02794242201201148,"score_gpt":0.2877062884297824,"score_spread":0.2597638664177709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}