{"id":"W4296330112","doi":"10.2340/actadv.v102.2269","title":"Sustained Resolution of Nail Psoriasis Through 5 Years with Ixekizumab: A Post-Hoc analysis from UNCOVER-3","year":2022,"lang":"en","type":"article","venue":"Acta Dermato Venereologica","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"LEO Pharma; Bausch Health; Simon Spies Fonden; Dermira; Regeneron Pharmaceuticals; Biogen; Celgene; Mylan; Janssen Pharmaceuticals; Gilead Sciences; Galderma; Bristol-Myers Squibb; Eli Lilly and Company; Pfizer; Samsung; National Psoriasis Foundation; Amgen","keywords":"Psoriasis; Medicine; Ixekizumab; Nail (fastener); Dermatology; Post-hoc analysis; Nail disease; Psoriasis Area and Severity Index; Internal medicine; Psoriatic arthritis; Secukinumab","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004996106,0.0009805089,0.003232174,0.0003178689,0.0003125607,0.000949611,0.0008348484,0.0006301251,0.003175655],"category_scores_gemma":[0.003276168,0.0003003714,0.004560374,0.0004138834,0.0003877379,0.0008414051,0.000655013,0.001832291,0.0003966224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004451057,"about_ca_system_score_gemma":0.0009086368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001278076,"about_ca_topic_score_gemma":0.001463433,"domain_scores_codex":[0.9971873,0.001440697,0.0001396678,0.0004053989,0.000325514,0.0005014724],"domain_scores_gemma":[0.9962373,0.001827121,0.0006318657,0.0005563012,0.000317526,0.0004298672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8407943,0.006492421,0.1073978,0.0006592866,0.01619536,0.0003772433,0.0002932939,0.001435393,0.005751476,0.0001101331,0.0020962,0.01839719],"study_design_scores_gemma":[0.04673113,0.2721823,0.6462634,0.00008828807,0.02119387,0.0004000137,0.0005850327,0.00489911,0.003788847,0.0001976238,0.003570377,0.00009997177],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981059,0.0004970717,0.0001888325,0.00003543139,0.00003700356,0.000116669,0.0006359211,0.00001314768,0.0003700061],"genre_scores_gemma":[0.9968979,0.0002064021,0.0002213345,0.00007450934,0.00005646827,0.0001973603,0.001312808,0.00001689297,0.001016263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004996106,"threshold_uncertainty_score":0.02642226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01202024384155639,"score_gpt":0.2182900166107102,"score_spread":0.2062697727691538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}