{"id":"W4296343725","doi":"10.1212/wnl.0000000000201300","title":"Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Cerebrospinal fluid and hydrocephalus","field":"Neuroscience","cited_by":339,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Japan Society for the Promotion of Science; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Canon Medical Systems Corporation; Northern California Institute for Research and Education; Japan Agency for Medical Research and Development; Promotion and Mutual Aid Corporation for Private Schools of Japan; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Glymphatic system; Cognition; Association (psychology); Disease; Cognitive impairment; Medicine; Amyloid (mycology); Alzheimer's disease; Pathology; Psychology; Neuroscience; Cerebrospinal fluid; Psychotherapist","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003779046,0.0003253127,0.0002942286,0.0008030828,0.0002838649,0.0003347822,0.0001771492,0.0003385427,0.001320618],"category_scores_gemma":[0.001023495,0.0001314697,0.0003208793,0.0004623673,0.0002502819,0.0002099073,0.0003005169,0.0002786296,0.0001493602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001563624,"about_ca_system_score_gemma":0.0001806315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003823804,"about_ca_topic_score_gemma":0.003826999,"domain_scores_codex":[0.9998658,0.0000318631,0.00002116274,0.00003263489,0.0000247604,0.00002371756],"domain_scores_gemma":[0.9993722,0.000101751,0.0002953897,0.00004224631,0.00005513927,0.0001333255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005289786,0.00003395239,0.9964938,0.00001148211,0.0001239922,0.0001126268,0.00003782606,0.00005747271,0.001036002,0.00001044737,0.00005541051,0.001498176],"study_design_scores_gemma":[0.000005950785,0.00006905978,0.9994439,0.000001101652,0.00001808114,0.000219157,0.00002941872,0.00007881822,0.00008542942,0.00001909319,0.00002844728,0.000001431335],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992568,0.0002146204,0.00007278132,0.00001807656,0.000003218495,0.000005073443,0.0001578489,0.00000431791,0.0002673249],"genre_scores_gemma":[0.9996693,0.00003226881,0.00007381776,0.000009138835,0.000007026809,0.000003547279,0.0001340038,8.251168e-7,0.00007005127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003823804,"threshold_uncertainty_score":0.007603109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01107785939015734,"score_gpt":0.2336614363723885,"score_spread":0.2225835769822311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}