{"id":"W4296344172","doi":"10.1161/circulationaha.121.058411","title":"Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Manitoba; St. Boniface Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; Children's Discovery Institute; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"TRAF2; Tumor necrosis factor alpha; Cardiotoxicity; Medicine; Cancer research; Ubiquitin ligase; Cell biology; Ubiquitin; Myocyte; Biology; Endocrinology; Internal medicine; Biochemistry; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003157131,0.0004285447,0.0002217223,0.0002192147,0.0002314636,0.0002598458,0.0001800107,0.0004169017,0.001824009],"category_scores_gemma":[0.000149068,0.0001324617,0.0002826063,0.00012956,0.0002818454,0.0002493752,0.0002303705,0.0004830935,0.0005376585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003440839,"about_ca_system_score_gemma":0.000146108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001939003,"about_ca_topic_score_gemma":0.0003121536,"domain_scores_codex":[0.9998636,0.00002404104,0.00001744301,0.00003207397,0.00002503311,0.00003776554],"domain_scores_gemma":[0.9998406,0.00001213557,0.00006592113,0.00001582344,0.00001714975,0.0000483744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005908243,0.00007197091,0.001332631,0.00006704762,0.00001125495,0.0003010577,0.00002020559,0.00004765873,0.9967476,0.00006349122,0.00007106279,0.0006751242],"study_design_scores_gemma":[0.0001695817,0.001314219,0.08037594,0.0000446424,0.00009247219,0.006347213,0.0001584943,0.002198071,0.9056022,0.0002179118,0.003463815,0.00001539666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951378,0.00222371,0.001533903,0.0001021424,0.00003725405,0.00002752668,0.0002378349,0.00003150792,0.0006683854],"genre_scores_gemma":[0.9979337,0.0006008165,0.0003718286,0.00004361641,0.0000141404,0.0000231035,0.0002762922,0.000005694462,0.0007307391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001824009,"threshold_uncertainty_score":0.006101966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01632925282432528,"score_gpt":0.2396688908224084,"score_spread":0.2233396379980831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}