{"id":"W4296344173","doi":"10.1101/2022.09.16.508329","title":"Genetic, Clinical Underpinnings of Brain Change Along Two Neuroanatomical Dimensions of Clinically-defined Alzheimer’s Disease","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Pfizer; Novartis Pharmaceuticals Corporation; F. Hoffmann-La Roche; Bristol-Myers Squibb; Eli Lilly and Company; Medical Research Council; Biogen; BioClinica; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Eisai; National Institute on Aging; Alzheimer's Association","keywords":"Atrophy; Apolipoprotein E; Population; Disease; Asymptomatic; Neuroscience; Alzheimer's disease; Pathology; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007688309,0.0003862427,0.0002829034,0.0008868394,0.0003222349,0.0005032718,0.0002702492,0.0003770685,0.001278425],"category_scores_gemma":[0.001886638,0.0001522641,0.0003859688,0.0005410183,0.0006001682,0.0001871801,0.0005358809,0.0004335228,0.0001213611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000258458,"about_ca_system_score_gemma":0.000243215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002611943,"about_ca_topic_score_gemma":0.003516997,"domain_scores_codex":[0.9995251,0.0001340008,0.00003987204,0.0001874488,0.00007234485,0.00004123119],"domain_scores_gemma":[0.999018,0.0002889585,0.0003508195,0.0001193289,0.00009695804,0.000125985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001435695,0.0001482883,0.9626762,0.0000316082,0.0004605513,0.000511024,0.0002628392,0.001569006,0.02635304,0.0005608127,0.000235867,0.005755167],"study_design_scores_gemma":[0.00001295253,0.00006622329,0.9945326,0.000003767358,0.00003520908,0.0003368387,0.00008068391,0.00376758,0.0005919095,0.0004810508,0.00008357337,0.000007582787],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990535,0.00004846283,0.0005208219,0.00002739205,0.000002620001,0.000006936756,0.0001290257,0.000005485108,0.0002057914],"genre_scores_gemma":[0.9995167,0.00001172613,0.0002882969,0.000006209807,0.000002596163,0.000004068771,0.0001137765,0.00000330815,0.00005338253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002611943,"threshold_uncertainty_score":0.005193472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07715542345101649,"score_gpt":0.3546637440025838,"score_spread":0.2775083205515673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}