{"id":"W4296351412","doi":"10.3389/fcell.2022.932510","title":"Prostate cancer cells of increasing metastatic potential exhibit diverse contractile forces, cell stiffness, and motility in a microenvironment stiffness-dependent manner","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Institut de Valorisation des Données; McGill University; Canada Excellence Research Chairs, Government of Canada; Prostate Cancer Canada; Canada Research Chairs","keywords":"DU145; Contractility; LNCaP; Tumor microenvironment; Metastasis; Cancer cell; Prostate cancer; Motility; Chemistry; Cell; Cancer research; Cancer; Biology; Cell biology; Medicine; Internal medicine; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002196654,0.0001672702,0.000246203,0.0001081989,0.0001074442,0.00001063257,0.00009215958,0.00006401854,0.0001163937],"category_scores_gemma":[0.000005911617,0.0001711011,0.00003529989,0.00006410732,0.00009695673,0.000009446162,0.0003914757,0.0001590395,6.04158e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009318138,"about_ca_system_score_gemma":0.00006913609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000636082,"about_ca_topic_score_gemma":0.0001242576,"domain_scores_codex":[0.9987798,0.00014364,0.0003158663,0.0004263862,0.00008037456,0.0002539583],"domain_scores_gemma":[0.9996982,0.00001301713,0.0001303612,0.00008655126,0.00001284674,0.00005907238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004974785,0.0002624505,0.02138498,0.00005513326,0.00003120832,0.00001910343,0.0002627391,0.00008930459,0.9733682,0.00000273981,0.0003080871,0.00371862],"study_design_scores_gemma":[0.005887961,0.0003243448,0.02758516,0.00003055093,0.00007346433,0.00007046904,0.01247937,0.001118249,0.9325358,0.0003005828,0.01897171,0.0006223084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953347,0.003228482,0.0002700735,0.00002323448,0.0004467745,0.0003322313,0.0002408167,0.000002524555,0.0001211249],"genre_scores_gemma":[0.9955382,0.001983918,0.001712871,0.00006407486,0.0000110306,0.00007502015,0.0002060421,0.00001295203,0.0003958536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04083232,"threshold_uncertainty_score":0.6977301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005591917640800481,"score_gpt":0.2065861757768452,"score_spread":0.2009942581360447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}