{"id":"W4296351412","doi":"10.3389/fcell.2022.932510","title":"Prostate cancer cells of increasing metastatic potential exhibit diverse contractile forces, cell stiffness, and motility in a microenvironment stiffness-dependent manner","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Institut de Valorisation des Données; McGill University; Canada Excellence Research Chairs, Government of Canada; Prostate Cancer Canada; Canada Research Chairs","keywords":"DU145; Contractility; LNCaP; Tumor microenvironment; Metastasis; Cancer cell; Prostate cancer; Motility; Chemistry; Cell; Cancer research; Cancer; Biology; Cell biology; Medicine; Internal medicine; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009945613,0.0002265564,0.0002146668,0.0003974707,0.0002322112,0.0003759925,0.00008466405,0.0001764397,0.0007485953],"category_scores_gemma":[0.000110583,0.0001460345,0.0001800735,0.0004073408,0.0001309872,0.000197669,0.0002225296,0.0003291797,0.0001954955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001359567,"about_ca_system_score_gemma":0.0001876086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001539979,"about_ca_topic_score_gemma":0.003207023,"domain_scores_codex":[0.9998732,0.00001328092,0.000008229983,0.00002302962,0.00005763589,0.0000245896],"domain_scores_gemma":[0.9999053,0.00001511358,0.00002296781,0.000007991459,0.00002504292,0.00002347343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002894374,0.00001758422,0.004753644,0.0000416799,0.000009769748,0.00006865389,0.00005598934,0.0001770902,0.9913088,0.00008746933,0.00006229911,0.003388027],"study_design_scores_gemma":[0.00001331915,0.0005816758,0.3526315,0.00002204913,0.00006645034,0.002364191,0.0004091225,0.004340152,0.6329253,0.0002691976,0.006334687,0.00004236981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907256,0.002636534,0.004280152,0.0001002513,0.000007032712,0.00002745172,0.0004570435,0.00007779653,0.001688143],"genre_scores_gemma":[0.9942291,0.001832277,0.002413273,0.00006212286,0.000006257497,0.00003541788,0.0004207671,0.000008842049,0.0009919162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001539979,"threshold_uncertainty_score":0.003062069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005591917640800481,"score_gpt":0.2065861757768452,"score_spread":0.2009942581360447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}