{"id":"W4296410493","doi":"10.1016/j.ijbiomac.2022.09.173","title":"Dual acting acid-cleavable self-assembling prodrug from hyaluronic acid and ciprofloxacin: A potential system for simultaneously targeting bacterial infections and cancer","year":2022,"lang":"en","type":"article","venue":"International Journal of Biological Macromolecules","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University","funders":"Medical Research Council; Inyuvesi Yakwazulu-Natali; National Research Foundation; Pennsylvania College of Health Sciences","keywords":"Ciprofloxacin; Prodrug; Chemistry; Antibacterial activity; Hyaluronic acid; Zeta potential; Drug delivery; In vitro; Antibiotics; Pharmacology; Microbiology; Medicine; Bacteria; Biochemistry; Biology; Materials science; Nanotechnology; Nanoparticle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001740504,0.0002978017,0.0001815155,0.0001288634,0.0001151694,0.0001758471,0.0001814915,0.0003996737,0.0009168154],"category_scores_gemma":[0.0001282929,0.0001244121,0.0001408619,0.0001000466,0.0001188232,0.0002471992,0.0001715254,0.0004193668,0.0002786134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002511846,"about_ca_system_score_gemma":0.000232157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004626666,"about_ca_topic_score_gemma":0.00075351,"domain_scores_codex":[0.9999093,0.0000160954,0.000006128124,0.00002186656,0.00002398132,0.00002266435],"domain_scores_gemma":[0.9999075,0.00001145114,0.00003235869,0.000006688594,0.00001328687,0.00002880925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006802893,0.00001381438,0.00003724725,0.00004459038,0.000002702057,0.00003875883,0.000005819974,0.00006071798,0.9966979,0.00009168718,0.00005967075,0.002879016],"study_design_scores_gemma":[0.00002275201,0.0003521191,0.0004378918,0.000003838219,0.000009810447,0.0001987124,0.000004871316,0.000505492,0.9958771,0.00001728717,0.002564273,0.000005740027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9489922,0.005125488,0.04058417,0.0003587095,0.0001583835,0.0002512394,0.0003865932,0.0002247943,0.003918399],"genre_scores_gemma":[0.9726491,0.001314177,0.01987311,0.0001344226,0.00002365386,0.00009762742,0.0002208908,0.00002263333,0.00566435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009168154,"threshold_uncertainty_score":0.003067017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01262862086448976,"score_gpt":0.2886186043915985,"score_spread":0.2759899835271088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}