{"id":"W4296453818","doi":"10.1002/dad2.12354","title":"Integrative analysis of DNA methylation and gene expression identifies genes associated with biological aging in Alzheimer's disease","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; U.S. National Library of Medicine; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"DNA methylation; Gene; Gene expression; Biology; Disease; Genetics; Methylation; DNA; Alzheimer's disease; Epigenetics; Computational biology; Bioinformatics; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003101332,0.0003547469,0.0003436731,0.001067815,0.0002133425,0.000254558,0.0001917554,0.0001358961,0.001070238],"category_scores_gemma":[0.0004192667,0.0001148676,0.0004851873,0.0009906074,0.0001625967,0.0001707855,0.0003579406,0.000150405,0.00009533933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002750708,"about_ca_system_score_gemma":0.0002883001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00270832,"about_ca_topic_score_gemma":0.003341106,"domain_scores_codex":[0.9998318,0.00003328333,0.000008288622,0.00006705552,0.00003020919,0.00002931278],"domain_scores_gemma":[0.9998326,0.0000363024,0.00006069219,0.00001452235,0.00003197153,0.00002389981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001332331,0.0001385912,0.3768487,0.0005038101,0.001434675,0.0003967502,0.0003254091,0.0104144,0.5206974,0.001396828,0.001188834,0.08532235],"study_design_scores_gemma":[0.00002556758,0.0002621788,0.9051867,0.00003370174,0.0006370356,0.0004881381,0.0001799372,0.04396814,0.04450971,0.002334404,0.002344172,0.00003022981],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855465,0.001190573,0.01079865,0.00005210087,0.000006781009,0.00002038588,0.001617105,0.00009936199,0.0006686565],"genre_scores_gemma":[0.9944991,0.0002610451,0.003731023,0.00001797554,0.00000457226,0.00001835674,0.001019509,0.00001237718,0.0004359731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00270832,"threshold_uncertainty_score":0.005385101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03013920772732975,"score_gpt":0.3162137956649558,"score_spread":0.286074587937626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}