{"id":"W4296466894","doi":"10.3390/cancers14194544","title":"Proteasome Inhibitors and Their Potential Applicability in Osteosarcoma Treatment","year":2022,"lang":"en","type":"review","venue":"Cancers","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Ontario Veterinary College, University of Guelph","keywords":"Osteosarcoma; Proteasome; Medicine; Mantle cell lymphoma; Multiple myeloma; Cancer research; Carfilzomib; Cancer; Oncology; Bioinformatics; Clinical trial; Metastasis; Lymphoma; Proteasome inhibitor; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004343812,0.00058769,0.001012323,0.001768357,0.0002455148,0.0008403799,0.0005491732,0.0007709184,0.003738525],"category_scores_gemma":[0.0004754841,0.0002269557,0.0006961733,0.001020887,0.000272006,0.0007086745,0.0005355495,0.001616792,0.001393165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004548212,"about_ca_system_score_gemma":0.0006145522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006085546,"about_ca_topic_score_gemma":0.00185502,"domain_scores_codex":[0.9998338,0.00002883945,0.00002624435,0.00002589648,0.00006426014,0.00002093268],"domain_scores_gemma":[0.9998513,0.00006474138,0.00002645993,0.000004368966,0.00003838797,0.0000146507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001409356,0.0001208628,0.0001957167,0.01527133,0.0001211606,0.0003605934,0.00006116213,0.0005386699,0.003258392,0.003171422,0.01845643,0.9583033],"study_design_scores_gemma":[0.00003918756,0.0002094599,0.0008870915,0.003417555,0.0001336726,0.001599553,0.00004175967,0.0001472329,0.00114507,0.001934156,0.9904262,0.00001906413],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002584155,0.9984523,0.0001003339,0.0001862375,0.0001076357,0.000005570289,0.00002248314,0.000007649979,0.0008593724],"genre_scores_gemma":[0.001431854,0.9976109,0.0001631273,0.0001486872,0.00008645367,0.000007239719,0.00004287921,0.000001380126,0.0005074317],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003738525,"threshold_uncertainty_score":0.0125066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02872559434270347,"score_gpt":0.2842047896173783,"score_spread":0.2554791952746748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}