{"id":"W4296468325","doi":"10.1016/s2152-2650(22)01359-3","title":"CML-047 Post Hoc Analysis of Responses to Ponatinib in Patients With Chronic-Phase Chronic Myeloid Leukemia (CP-CML) by Baseline BCR::ABL1 Level and Baseline Mutation Status in the OPTIC Trial","year":2022,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Ponatinib; Internal medicine; Cohort; Population; Myeloid leukemia; Imatinib; Dasatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003245032,0.001152998,0.003224979,0.000254908,0.0002446453,0.0011424,0.0008372364,0.0007227503,0.004596633],"category_scores_gemma":[0.003250214,0.0003325168,0.003314717,0.0003723527,0.0007934516,0.001170017,0.000651025,0.00195971,0.0005199924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007793159,"about_ca_system_score_gemma":0.001097422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006929394,"about_ca_topic_score_gemma":0.001564093,"domain_scores_codex":[0.9977044,0.001493735,0.00009844082,0.0003267094,0.0001107674,0.000265954],"domain_scores_gemma":[0.998456,0.0007205629,0.0002659121,0.0001920969,0.00008384379,0.0002816608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9686394,0.0005718251,0.008694298,0.0002672831,0.006404977,0.00005437238,0.000046553,0.0009851136,0.002527574,0.0001964952,0.001584707,0.01002747],"study_design_scores_gemma":[0.5510781,0.2092321,0.1855912,0.0001163167,0.02187195,0.0003895659,0.000408413,0.01456861,0.00542725,0.001917582,0.009206754,0.0001921557],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954353,0.001044475,0.0003339231,0.0002854692,0.0001637693,0.0001885983,0.001075211,0.00004328769,0.001429967],"genre_scores_gemma":[0.9958283,0.0002516051,0.0003732362,0.0002398782,0.0001310865,0.0002836518,0.001228096,0.00002288865,0.001641371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004596633,"threshold_uncertainty_score":0.01716155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02755615042185004,"score_gpt":0.3304778041480667,"score_spread":0.3029216537262167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}