{"id":"W4296468442","doi":"10.1016/s2152-2650(22)01463-x","title":"MPN-478 MOMENTUM: Phase 3 Randomized Study of Momelotinib (MMB) versus Danazol (DAN) in Symptomatic and Anemic Myelofibrosis (MF) Patients Previously Treated With a JAK Inhibitor","year":2022,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Myelofibrosis; Ruxolitinib; Placebo; Gastroenterology; Anemia; Internal medicine; Danazol; Clinical endpoint; Hematocrit; Randomized controlled trial; Surgery; Bone marrow; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001328891,0.001488167,0.002334133,0.0004061057,0.000389592,0.001468467,0.0008725571,0.001209341,0.007177371],"category_scores_gemma":[0.001196417,0.0007049012,0.001653153,0.0004124111,0.001050488,0.001049394,0.0004197985,0.004028102,0.001256152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008869999,"about_ca_system_score_gemma":0.001198609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001348527,"about_ca_topic_score_gemma":0.003891215,"domain_scores_codex":[0.9996289,0.0001890074,0.00001628448,0.00005746256,0.00002642432,0.00008183988],"domain_scores_gemma":[0.9994049,0.0001401079,0.0001057863,0.00004290711,0.00002591953,0.000280287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9595025,0.008017493,0.0009689226,0.0003757533,0.001103204,0.00005290912,0.00005176808,0.0006622378,0.003988475,0.0002063264,0.001793463,0.02327697],"study_design_scores_gemma":[0.9474168,0.04793895,0.002132266,0.00002720783,0.0004641094,0.00004571068,0.00002699228,0.000572848,0.0003436754,0.0001868399,0.0008295446,0.00001520765],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872048,0.004077244,0.0006478393,0.001260891,0.000474647,0.001648841,0.001525816,0.0001992366,0.002960676],"genre_scores_gemma":[0.9864981,0.002708829,0.001358667,0.0016029,0.0003723968,0.002091662,0.00178765,0.00004656039,0.003533134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007177371,"threshold_uncertainty_score":0.02401072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02301111318952972,"score_gpt":0.3175666139506708,"score_spread":0.2945555007611411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}