{"id":"W4296468504","doi":"10.1016/s2152-2650(22)01293-9","title":"AML-432 Overall Survival (OS) by Mutant Allele (R140 or R172) in Patients With Late-Stage, Mutant- Relapsed/Refractory Acute Myeloid Leukemia (AML) Treated With Enasidenib or Conventional Care Regimens (CCR) in the Randomized, Open-Label, Phase 3 IDHENTIFY Trial","year":2022,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Medical Research Council","keywords":"Medicine; Internal medicine; NPM1; Oncology; Myeloid leukemia; Cohort; Refractory (planetary science); Gastroenterology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001327321,0.001029274,0.001821458,0.0002111863,0.0002402009,0.001092426,0.0005356172,0.0007770631,0.003006092],"category_scores_gemma":[0.0006229539,0.0003268933,0.001531529,0.0002901158,0.0007420976,0.0007581984,0.0004236014,0.00255594,0.0004612812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006640637,"about_ca_system_score_gemma":0.0008485617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006288967,"about_ca_topic_score_gemma":0.00239716,"domain_scores_codex":[0.9995734,0.0002250621,0.00001515048,0.00007369898,0.00002700695,0.00008569533],"domain_scores_gemma":[0.9996493,0.00007735924,0.00007571156,0.00002937727,0.00001580138,0.0001525061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9399672,0.004218763,0.006718506,0.0004143761,0.001585677,0.00007761316,0.00008253971,0.00178128,0.008117652,0.000403968,0.002909892,0.03372261],"study_design_scores_gemma":[0.7953638,0.1594403,0.03244904,0.0000832467,0.002431679,0.000273326,0.0001202778,0.002647341,0.002493701,0.001052187,0.003584971,0.00006004956],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958991,0.001653406,0.0001586578,0.0003318017,0.0001084756,0.0001584255,0.0006201016,0.00004691283,0.001022991],"genre_scores_gemma":[0.9950954,0.001005218,0.0003251026,0.0005217044,0.000130122,0.0002787305,0.001424626,0.00001530511,0.00120375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003006092,"threshold_uncertainty_score":0.01005644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04589684260690143,"score_gpt":0.3575394815419613,"score_spread":0.3116426389350599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}