{"id":"W4296514561","doi":"10.1136/gutjnl-2022-basl.60","title":"P09 Long-term obeticholic acid (OCA) for Primary Biliary Cholangitis (PBC) in a clinical trial improved event free survival (death, liver transplant and hepatic decompensation) compared to external controls from the GLOBAL PBC real-world database","year":2022,"lang":"en","type":"article","venue":"Abstracts","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Toronto General Hospital; University of Toronto","funders":"","keywords":"Syk; Biology; Innate immune system; Immunology; Effector; Immune system; Candida albicans; Inflammation; Cancer research; Receptor; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006278032,0.0003732681,0.001000399,0.0002913639,0.000191565,0.000532117,0.0002796372,0.0004434883,0.00551785],"category_scores_gemma":[0.0003153209,0.0001509627,0.0006334592,0.0003856592,0.0002628421,0.0002868634,0.0002457298,0.001019834,0.0004741858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002231464,"about_ca_system_score_gemma":0.0006847734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005111945,"about_ca_topic_score_gemma":0.001922722,"domain_scores_codex":[0.9997599,0.0001030109,0.00002349964,0.00003231127,0.00003186419,0.00004947243],"domain_scores_gemma":[0.9997492,0.00003779732,0.000066794,0.00002319861,0.00002429837,0.0000986707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7216141,0.01350018,0.00487147,0.0020121,0.001337685,0.0002137882,0.00006239166,0.0007037797,0.1026317,0.0003874062,0.004780374,0.1478852],"study_design_scores_gemma":[0.2918139,0.593887,0.05984286,0.0003292168,0.002358621,0.0008366306,0.0001394136,0.001619387,0.02902588,0.0003256379,0.01975693,0.0000645336],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858046,0.006338467,0.0005473253,0.0004589202,0.0002456534,0.0009076041,0.003077731,0.0001237632,0.002495946],"genre_scores_gemma":[0.9857669,0.003591005,0.001280042,0.0003922426,0.00008691433,0.0008153341,0.003940136,0.00002089683,0.004106643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00551785,"threshold_uncertainty_score":0.01845902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0579431235591201,"score_gpt":0.347384898055258,"score_spread":0.2894417744961378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}