{"id":"W4296523815","doi":"10.2174/1389450123666220908095121","title":"A Perspective on EGFR and Proteasome-based Targeted Therapy forCancer","year":2022,"lang":"en","type":"review","venue":"Current Drug Targets","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"All India Council for Technical Education","keywords":"Proteasome; Cancer; Cancer research; Tyrosine kinase; Medicine; Signal transduction; Targeted therapy; Kinase; Receptor tyrosine kinase; Cancer cell; Pharmacology; Bioinformatics; Biology; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008540656,0.0007723151,0.0007048469,0.00116075,0.0002793145,0.001126464,0.000646531,0.001820108,0.006007402],"category_scores_gemma":[0.0005409783,0.0001393323,0.0006334828,0.0008769947,0.0007059352,0.002643199,0.0006901214,0.003327614,0.002238978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009377067,"about_ca_system_score_gemma":0.0008908313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004369452,"about_ca_topic_score_gemma":0.001212973,"domain_scores_codex":[0.9996454,0.00009145778,0.00002778505,0.00006098087,0.0001209829,0.00005352945],"domain_scores_gemma":[0.9997075,0.0001121416,0.00003870566,0.00001201675,0.00008904513,0.00004049218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002894623,0.0002818987,0.0003408605,0.008997119,0.0001052179,0.0009189351,0.0002105231,0.0007798373,0.0126096,0.05395116,0.1380032,0.7835122],"study_design_scores_gemma":[0.00002877752,0.0003563084,0.0004079404,0.0009922737,0.00004184202,0.001291046,0.00007171382,0.0002080978,0.001164076,0.009320655,0.986099,0.00001834647],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005957895,0.9814469,0.001253096,0.008853424,0.002001854,0.00001314388,0.00004981524,0.00003214805,0.005753803],"genre_scores_gemma":[0.005886963,0.9800057,0.001343453,0.005024262,0.00289767,0.00002695038,0.00007546409,0.00001042449,0.004729053],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006007402,"threshold_uncertainty_score":0.02009678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05439472471592399,"score_gpt":0.3459025777545804,"score_spread":0.2915078530386565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}