{"id":"W4296528992","doi":"10.1016/s2152-2650(22)01358-1","title":"CML-046 Dose Modification Dynamics of Ponatinib in Patients With Chronic-Phase Chronic Myeloid Leukemia From the PACE and OPTIC Trials","year":2022,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ponatinib; Medicine; Adverse effect; Internal medicine; Myeloid leukemia; Dosing; Oncology; Dasatinib; Imatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003609225,0.0004785921,0.001779316,0.0003003986,0.0002529296,0.001115524,0.0004377976,0.000598349,0.003222741],"category_scores_gemma":[0.005073739,0.0002126024,0.001953722,0.0006090886,0.0003608779,0.001320523,0.0005388429,0.001928389,0.0004896921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009047182,"about_ca_system_score_gemma":0.001101345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000849202,"about_ca_topic_score_gemma":0.002114513,"domain_scores_codex":[0.9985846,0.0006321615,0.0001305011,0.0002481596,0.0002120167,0.0001926081],"domain_scores_gemma":[0.9982817,0.000606232,0.000501341,0.000191132,0.0001633386,0.0002562202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5122522,0.002396741,0.05936239,0.001767549,0.00779882,0.0002166755,0.0003278136,0.01416519,0.009736862,0.00217139,0.02333292,0.3664715],"study_design_scores_gemma":[0.2407361,0.1278773,0.478234,0.0004709644,0.01346983,0.001846841,0.0005736204,0.01639227,0.009230925,0.008243392,0.1025985,0.0003263429],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768197,0.007009113,0.0007717296,0.001588796,0.0001438166,0.000329248,0.006417029,0.0000822479,0.00683828],"genre_scores_gemma":[0.9872278,0.00196463,0.0008111808,0.0008052528,0.0001436584,0.000280238,0.007266123,0.00003994806,0.001461073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003609225,"threshold_uncertainty_score":0.01908761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03763956775805979,"score_gpt":0.3360157777617022,"score_spread":0.2983762100036425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}