{"id":"W4296529438","doi":"10.1016/s2152-2650(22)00691-7","title":"Oral Abstract: AML-295 AGILE: A Global, Randomized, Double-Blind, Phase 3 Study of Ivosidenib + Azacitidine Versus Placebo + Azacitidine in Patients With Newly Diagnosed Acute Myeloid Leukemia With an IDH1 Mutation","year":2022,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Azacitidine; Myeloid leukemia; Medicine; Placebo; IDH1; Oncology; Internal medicine; Mutation; Biology; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001050054,0.001937689,0.003053918,0.0004574757,0.0006357051,0.001463031,0.001235713,0.002554571,0.04739136],"category_scores_gemma":[0.001263613,0.0006626724,0.001813724,0.0003328108,0.0009201636,0.0007817258,0.000505954,0.003782765,0.004377656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006096346,"about_ca_system_score_gemma":0.001183406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009976537,"about_ca_topic_score_gemma":0.002026851,"domain_scores_codex":[0.9996656,0.0001503365,0.00002117714,0.00007172214,0.00003485574,0.00005636508],"domain_scores_gemma":[0.9994534,0.0001258506,0.0001108154,0.00002420054,0.00003202429,0.0002537861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9515356,0.003801354,0.000280685,0.001453808,0.001200105,0.00004963957,0.00003709028,0.0003602253,0.002984315,0.0003880373,0.009386715,0.02852251],"study_design_scores_gemma":[0.9791545,0.01677969,0.0008308861,0.0000581682,0.0003272475,0.00001465905,0.00001343947,0.0001503579,0.000339065,0.0001560395,0.002164287,0.00001170012],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.824962,0.03947198,0.006217852,0.01416979,0.01334326,0.03389123,0.02743262,0.0028936,0.03761759],"genre_scores_gemma":[0.9116368,0.01143813,0.004696101,0.01183887,0.003075298,0.01173271,0.007590479,0.0002573539,0.03773434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04739136,"threshold_uncertainty_score":0.1585399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04273344456218377,"score_gpt":0.3645151090393783,"score_spread":0.3217816644771946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}