{"id":"W4296533948","doi":"10.1016/s2152-2650(22)01262-9","title":"AML-295 AGILE: A Global, Randomized, Double-Blind, Phase 3 Study of Ivosidenib + Azacitidine Versus Placebo + Azacitidine in Patients With Newly Diagnosed Acute Myeloid Leukemia With an IDH1 Mutation","year":2022,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Azacitidine; Myeloid leukemia; Isocitrate dehydrogenase; IDH1; Internal medicine; Placebo; Adverse effect; Gastroenterology; Mutation; Biology; Enzyme; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00114847,0.001645404,0.002857913,0.0005287293,0.0004113115,0.001072853,0.0009740043,0.001277447,0.006242584],"category_scores_gemma":[0.0009866229,0.0006629618,0.001615291,0.0003982653,0.001303651,0.0008843666,0.000518095,0.003026366,0.0009771711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006447054,"about_ca_system_score_gemma":0.001244286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001328799,"about_ca_topic_score_gemma":0.003280096,"domain_scores_codex":[0.9995801,0.0002293282,0.00001854257,0.00007759965,0.00002935194,0.00006514323],"domain_scores_gemma":[0.9995099,0.0001224021,0.00008907823,0.00003148473,0.00002643491,0.0002205894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9620396,0.005655131,0.0006913821,0.0005608592,0.001113868,0.00003149751,0.00006244059,0.0005069843,0.005000767,0.0001878847,0.001026119,0.02312359],"study_design_scores_gemma":[0.9666527,0.03064569,0.00117701,0.0000181725,0.0002986115,0.00002096914,0.0000209677,0.0002556436,0.0003315812,0.0001182754,0.0004500701,0.00001042363],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823179,0.006069823,0.001409968,0.0009340663,0.000503218,0.003425385,0.001524762,0.0004227262,0.00339221],"genre_scores_gemma":[0.9850942,0.003126423,0.002331646,0.001794544,0.0003167026,0.002656789,0.001576409,0.00005846896,0.003044792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006242584,"threshold_uncertainty_score":0.0208835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03753250305841633,"score_gpt":0.358132601442889,"score_spread":0.3206000983844727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}