{"id":"W4296613884","doi":"10.3390/pharmaceutics14101992","title":"Bactericidal Activity of Carvacrol against Streptococcus pyogenes Involves Alteration of Membrane Fluidity and Integrity through Interaction with Membrane Phospholipids","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Essential Oils and Antimicrobial Activity","field":"Agricultural and Biological Sciences","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Nova Scotia Health Authority; Izaak Walton Killam Health Centre; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Carvacrol; Membrane fluidity; Streptococcus pyogenes; Membrane; Chemistry; Phosphatidylcholine; Membrane permeability; Biochemistry; Microbiology; Biology; Chromatography; Bacteria; Phospholipid; Essential oil","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001125863,0.0003985557,0.000237522,0.0002368341,0.0001383874,0.0002483288,0.0001719354,0.0003396664,0.000950503],"category_scores_gemma":[0.0001381593,0.0000878421,0.0002882929,0.00012682,0.0002842005,0.0002425388,0.0001333733,0.0002964824,0.0001743946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003211388,"about_ca_system_score_gemma":0.0002506485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007224514,"about_ca_topic_score_gemma":0.0005042816,"domain_scores_codex":[0.999878,0.00001874262,0.00001093097,0.00002319509,0.00003810115,0.0000308803],"domain_scores_gemma":[0.9998837,0.00002580724,0.00003524465,0.000009777812,0.00003182656,0.00001361978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005948958,0.00001344148,0.0002740245,0.00006179899,0.000003633098,0.00003198986,0.000009872432,0.00003043245,0.9982623,0.00002360058,0.00001105871,0.001218211],"study_design_scores_gemma":[0.000007095615,0.0002775606,0.00612015,0.000007256329,0.00001198382,0.0001770828,0.00002937373,0.0003382602,0.9922708,0.00002500872,0.0007316573,0.00000373558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944019,0.002990556,0.00149337,0.00006910336,0.00001597353,0.00003027743,0.0001607877,0.00003779229,0.0008002935],"genre_scores_gemma":[0.9977289,0.0009912292,0.0006539671,0.0000273845,0.000005959628,0.00001361739,0.0001333532,0.000003553613,0.0004420165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000950503,"threshold_uncertainty_score":0.003179789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04759745117157699,"score_gpt":0.281914653910729,"score_spread":0.234317202739152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}