{"id":"W4296613884","doi":"10.3390/pharmaceutics14101992","title":"Bactericidal Activity of Carvacrol against Streptococcus pyogenes Involves Alteration of Membrane Fluidity and Integrity through Interaction with Membrane Phospholipids","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Essential Oils and Antimicrobial Activity","field":"Agricultural and Biological Sciences","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Nova Scotia Health Authority; Izaak Walton Killam Health Centre; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Carvacrol; Membrane fluidity; Streptococcus pyogenes; Membrane; Chemistry; Phosphatidylcholine; Membrane permeability; Biochemistry; Microbiology; Biology; Chromatography; Bacteria; Phospholipid; Essential oil","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002148968,0.0001640917,0.0002948555,0.00001353001,0.0002285093,0.00002817821,0.0001392521,0.00004559212,0.0001758196],"category_scores_gemma":[0.00001331795,0.00007982603,0.0000766702,0.0002654804,0.0001276761,0.000351604,0.0001625565,0.0003010441,3.818161e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000322141,"about_ca_system_score_gemma":0.00001922886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001118541,"about_ca_topic_score_gemma":0.0003442556,"domain_scores_codex":[0.9989101,0.0001854614,0.0002352377,0.0002612192,0.0002308491,0.0001771091],"domain_scores_gemma":[0.9993778,0.0001364253,0.0002740649,0.00006053949,0.00009845959,0.00005267994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003597016,0.0004098785,0.005725693,0.0000866277,0.00004400376,0.000001984171,0.000274271,0.0001695192,0.9690691,0.00002157448,0.00001881336,0.0238189],"study_design_scores_gemma":[0.0003181229,0.0002842115,0.006554711,0.00002059756,0.00004806489,0.000006653779,0.0003045424,0.001030175,0.9890445,0.00001286859,0.00222267,0.0001528089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987093,0.00006663014,0.00002301293,0.0003311991,0.0002108624,0.0002697055,0.0002654728,0.00002703853,0.00009682482],"genre_scores_gemma":[0.9992287,0.0003965439,0.00007084879,0.0001070852,0.00009719605,0.00001611632,0.00006746237,0.000002210093,0.00001382842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02366609,"threshold_uncertainty_score":0.3255211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04759745117157699,"score_gpt":0.281914653910729,"score_spread":0.234317202739152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}