{"id":"W4296641474","doi":"10.1016/j.jacbts.2022.05.002","title":"Plasminogen Activator Inhibitor-1–Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype","year":2022,"lang":"en","type":"article","venue":"JACC Basic to Translational Science","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute; University of Ottawa","funders":"","keywords":"Mace; Plasminogen activator inhibitor-1; Proinflammatory cytokine; Medicine; Extracellular; Biomarker; Plasminogen activator; Extracellular vesicle; Extracellular vesicles; Coronary artery disease; Platelet activation; Platelet; Internal medicine; Cardiology; Myocardial infarction; Inflammation; Microvesicles; Cell biology; Chemistry; Biology; Percutaneous coronary intervention; Biochemistry; microRNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000886649,0.0001833386,0.0001318741,0.0000718466,0.0008556333,0.00007360106,0.0005242021,0.00004996771,0.00007616197],"category_scores_gemma":[0.0001117182,0.0001579243,0.00007060598,0.0003461744,0.0007955012,0.00003320667,0.0002663493,0.0001781254,0.000008796352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004333428,"about_ca_system_score_gemma":0.0004365199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009674224,"about_ca_topic_score_gemma":0.000007507651,"domain_scores_codex":[0.997941,0.0001571119,0.0002467161,0.0006171269,0.0006909805,0.0003470631],"domain_scores_gemma":[0.9991952,0.00007913975,0.00009322429,0.0003305819,0.00008205669,0.000219859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007209321,0.00006090156,0.0007493487,0.000009145526,0.00002299785,0.00001026052,0.000730589,0.001232979,0.9898584,0.001980482,0.0001966401,0.004427264],"study_design_scores_gemma":[0.002472125,0.0002163906,0.03885699,0.00001495044,0.00003481513,0.00005039586,0.0003409832,0.001747503,0.9425653,0.001086816,0.0121962,0.0004175872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942073,0.001430097,0.001376192,0.001499392,0.0001533508,0.0007758383,0.0001066459,0.00002312279,0.000428127],"genre_scores_gemma":[0.9978198,0.00001076922,0.001242096,0.0003587126,0.0001816359,0.0001451769,0.00004193549,0.00002213075,0.0001777316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04729323,"threshold_uncertainty_score":0.6580926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00731697477948789,"score_gpt":0.2216108091077059,"score_spread":0.2142938343282181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}