{"id":"W4296663123","doi":"10.1016/j.stemcr.2022.08.010","title":"Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson’s disease","year":2022,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"H2020 European Research Council; Horizon 2020; Medical Research Council; European Research Council; Fonds de Recherche du Québec - Santé; Parkinson Canada; Vetenskapsrådet; Lunds Universitet; Canada Research Chairs; NIHR Cambridge Biomedical Research Centre; European Commission; National Institute for Health and Care Research; Canada Foundation for Innovation; Parkinsonfonden; Hjärnfonden; Stiftelsen Olle Engkvist Byggmästare; New York Stem Cell Foundation; Cure Parkinson's Trust; Wellcome Trust; Department of Health and Social Care; Horizon 2020 Framework Programme; Cure Parkinson’s Trust","keywords":"Biology; Dopaminergic; Pathological; Disease; Parkinson's disease; Neuroscience; Degenerative disease; Dopamine; Pathology; Central nervous system disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003102922,0.000427299,0.0006408433,0.0001834755,0.0002366128,0.00003491012,0.0001173178,0.0000853719,0.0001864362],"category_scores_gemma":[0.00003349509,0.000340664,0.0002112239,0.0004686099,0.00007436755,0.00007966352,0.0002283069,0.0004071789,0.00001309244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003527108,"about_ca_system_score_gemma":0.0002357827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002097263,"about_ca_topic_score_gemma":0.00001660315,"domain_scores_codex":[0.9960353,0.0003454212,0.0007769038,0.001289249,0.0009389347,0.0006141442],"domain_scores_gemma":[0.9978121,0.00002891042,0.0004892481,0.0009388646,0.00006415417,0.000666719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001070917,0.003795596,0.7885388,0.00003995525,0.00007865056,0.2019529,0.0001872884,0.00006462655,0.0007947091,0.00000107382,0.00003085277,0.003444662],"study_design_scores_gemma":[0.005135218,0.001211613,0.9895136,0.0001178708,0.0003839381,0.0002479814,0.000131055,0.00008038181,0.0003657179,0.0001576278,0.002295415,0.0003595499],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995444,0.001589536,0.000006450142,0.00006129764,0.0004132851,0.001622628,0.00008526763,0.0002254432,0.0005521185],"genre_scores_gemma":[0.9975722,0.00003492298,0.0001042057,0.0001748907,0.00002468466,0.0007966486,0.0007332751,0.00007656545,0.0004825815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2017049,"threshold_uncertainty_score":0.9999045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01008576915875504,"score_gpt":0.2161363375117353,"score_spread":0.2060505683529803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}