{"id":"W4296663219","doi":"10.1016/j.ajhg.2022.09.002","title":"The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans","year":2022,"lang":"en","type":"article","venue":"The American Journal of Human Genetics","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; NIHR Imperial Biomedical Research Centre; Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; National Institutes of Health; Novo Nordisk Fonden; Svend Andersen Fonden; Universiteit Leiden; Leids Universitair Medisch Centrum; Canadian Institutes of Health Research; Danmarks Frie Forskningsfond; Merck; Deutsche Forschungsgemeinschaft; Radboud Universitair Medisch Centrum; Novo Nordisk; National Institute for Health and Care Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Radboud Universiteit","keywords":"Piwi-interacting RNA; Meiosis; Spermatogenesis; Biology; Line (geometry); Cell biology; Genetics; Expression (computer science); Gene; Genome; Computer science; Transposable element; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001571272,0.0003700462,0.0005367525,0.0008958862,0.0002783145,0.0004095044,0.0003548598,0.0004400491,0.003099869],"category_scores_gemma":[0.000393458,0.000332661,0.0003404974,0.0004312622,0.0004452853,0.0001747832,0.0003918238,0.0004353703,0.0006185354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000158255,"about_ca_system_score_gemma":0.000143041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008363533,"about_ca_topic_score_gemma":0.0008032577,"domain_scores_codex":[0.9996941,0.00004761944,0.0000441433,0.0001153172,0.00007230175,0.00002656507],"domain_scores_gemma":[0.9996865,0.00006849637,0.0001205051,0.00004636456,0.00001894423,0.00005923617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001009327,0.00003377161,0.01002211,0.0001463552,0.0001446613,0.002853867,0.0001407623,0.0003216561,0.9748648,0.0009029163,0.0002816765,0.009278107],"study_design_scores_gemma":[0.0003526872,0.0007660429,0.5712869,0.0001445267,0.0008621382,0.04478757,0.0002697717,0.004494133,0.3490509,0.002362587,0.02552133,0.0001014363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914417,0.002300741,0.003613554,0.0001110936,0.00004479982,0.00001123401,0.0009454984,0.0001853833,0.00134611],"genre_scores_gemma":[0.9969677,0.0003705162,0.001247789,0.00005258718,0.0000178053,0.0000063471,0.0005081188,0.00005438712,0.000774745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003099869,"threshold_uncertainty_score":0.01037008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02254531465217059,"score_gpt":0.2584361027728411,"score_spread":0.2358907881206705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}