{"id":"W4296663392","doi":"10.1016/j.ccell.2022.08.015","title":"MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Cell","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Janssen Pharmaceuticals; National Institute of General Medical Sciences; Japan Society for the Promotion of Science; Ludwig Center at Harvard; Takeda Oncology; EMD Serono; National Institutes of Health; Eli Lilly and Company; Associazione Italiana per la Ricerca sul Cancro; Princess Takamatsu Cancer Research Fund; Revolution Medicines; Array BioPharma; Robert A. and Renee E. Belfer Family Foundation; Lilly Oncology; Boehringer Ingelheim; Takeda Pharmaceuticals U.S.A.; Takeda Science Foundation; National Cancer Institute; Foghorn Therapeutics; Gilead Sciences; Dana-Farber Cancer Institute; Japan Agency for Medical Research and Development; Uehara Memorial Foundation; Novartis; AbbVie; Northeastern University; Merck; Dana-Farber/Harvard Cancer Center; AstraZeneca; Canadian Asian Studies Association; Expect Miracles Foundation","keywords":"Cancer research; Intracellular; Apoptosis; Programmed cell death; Biology; In vivo; Cell biology; Sting","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001459295,0.0004078695,0.0003258783,0.000182345,0.0001753052,0.0003424426,0.0001464016,0.0003178138,0.002932285],"category_scores_gemma":[0.0001631505,0.0001373191,0.0002584082,0.0000859968,0.0002090495,0.0002060999,0.0001956006,0.001330094,0.0005182247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003456115,"about_ca_system_score_gemma":0.0003650977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003897737,"about_ca_topic_score_gemma":0.0006564899,"domain_scores_codex":[0.9997844,0.00004724502,0.00001297155,0.00002190384,0.00003541929,0.0000980066],"domain_scores_gemma":[0.9998811,0.00002817162,0.00002262654,0.00001748483,0.000009567915,0.00004096504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002372848,0.0002785885,0.0003814985,0.00007584128,0.00001494639,0.00007399799,0.00002795164,0.0002920939,0.9919304,0.0002215514,0.0005133685,0.003816894],"study_design_scores_gemma":[0.0003064747,0.004434962,0.009849434,0.00002715193,0.00004382352,0.0003953094,0.0001675951,0.002455874,0.9766157,0.000281267,0.005407954,0.00001463123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969572,0.0005576378,0.0003076272,0.0001981646,0.0001113731,0.00002362558,0.0002319766,0.00006652956,0.001545916],"genre_scores_gemma":[0.9978163,0.0001989025,0.0001807301,0.00007652119,0.00002566926,0.00002167958,0.0002148164,0.00001083342,0.001454493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002932285,"threshold_uncertainty_score":0.009809434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008493374383985472,"score_gpt":0.2553160615356873,"score_spread":0.2468226871517018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}