{"id":"W4296687832","doi":"10.1172/jci160101","title":"Mesenchymal cell replacement corrects thymic hypoplasia in murine models of 22q11.2 deletion syndrome","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Texas Southwestern Medical Center; Jeffrey Modell Foundation","keywords":"Mesenchymal stem cell; Mesenchyme; Biology; Embryonic stem cell; Cell biology; Extracellular matrix; DiGeorge syndrome; Pathology; Immunology; Genetics; Medicine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003848594,0.0005380836,0.0005704464,0.0007003139,0.0002747049,0.0006146889,0.0003928413,0.0007838633,0.002087301],"category_scores_gemma":[0.0002886642,0.0003198092,0.000572075,0.0002051109,0.0004333241,0.0002889495,0.0004861145,0.001774352,0.0005550023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002633673,"about_ca_system_score_gemma":0.0003405714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005400914,"about_ca_topic_score_gemma":0.001228617,"domain_scores_codex":[0.9994899,0.00006910057,0.00005398953,0.000121189,0.0001644548,0.0001013577],"domain_scores_gemma":[0.9996768,0.0000389875,0.00008744308,0.00003454902,0.00003638561,0.0001258014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003534603,0.0001578389,0.0004665318,0.0001951433,0.00003308146,0.0003459194,0.00006691905,0.0002898388,0.9929898,0.0003508992,0.0003258155,0.004424769],"study_design_scores_gemma":[0.0003217232,0.002440411,0.01175115,0.000158531,0.0002772599,0.001851767,0.0003230671,0.003358585,0.9483274,0.0004802519,0.03066231,0.0000474542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781098,0.005599611,0.008805401,0.0005440281,0.0004413083,0.0001992658,0.002731832,0.0008037006,0.002765083],"genre_scores_gemma":[0.9767932,0.004105442,0.005798304,0.0004035438,0.00005799556,0.0002860029,0.003070513,0.0001935288,0.00929143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002087301,"threshold_uncertainty_score":0.006982684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05526872546128318,"score_gpt":0.3518786491832309,"score_spread":0.2966099237219477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}