{"id":"W4296690345","doi":"10.1038/s41591-022-01942-9","title":"Temporal order of clinical and biomarker changes in familial frontotemporal dementia","year":2022,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":false,"ca_institutions":"Baycrest Hospital; McGill University; Toronto Rehabilitation Institute; Douglas Mental Health University Institute; Université Laval; University of Toronto; Western University; Sunnybrook Health Science Centre; Health Sciences Centre; Occupational Cancer Research Centre; University Health Network; Montreal Neurological Institute and Hospital; University of British Columbia","funders":"David Geffen School of Medicine, University of California, Los Angeles; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Janssen Pharmaceuticals; National Institute on Aging; University College London; NIHR Cambridge Biomedical Research Centre; Tau Consortium; Brain Research UK; Bayer Vital; National Institute of Neurological Disorders and Stroke; Houston Methodist Research Institute; Ministero della Salute; Faculté de Médecine, Université Laval; Pfizer; Centre National de la Recherche Scientifique; Parkinsonfonden; National Institutes of Health; Università degli Studi di Milano; Buck Institute for Research on Aging; Instituto de Salud Carlos III; UK Dementia Research Institute; Sahlgrenska Akademin; Institut National de la Santé et de la Recherche Médicale; H. Lundbeck A/S; Sorbonne Université; Universiteit Antwerpen; Medical Research Council; Vetenskapsrådet; TauRx Pharmaceuticals; Università degli Studi di Brescia; Eli Lilly and Company; Universidade de Lisboa; Göteborgs Universitet; Universidade de Coimbra; Deutsches Zentrum für Neurodegenerative Erkrankungen; Universitat de Barcelona; Université de Lille; Karolinska Institutet; FONDATION ALZHEIMER; Eisai; School of Medicine, Indiana University; Stockholms Läns Landsting; KU Leuven; Cambridge University Hospitals; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; Fondation Brain Canada; Toronto Rehabilitation Institute; Weston Brain Institute; Deutsche Forschungsgemeinschaft; University of North Carolina at Chapel Hill; Wolfson Foundation; University of Toronto; Imperial College London; University of Cambridge; National Institute for Health and Care Research; Puma Biotechnology; University of California, San Francisco; Canadian Institutes of Health Research; Alzheimer's Society; Novartis; Ionis Pharmaceuticals; Università degli Studi di Firenze; University of California, Los Angeles; Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta; University Health Network; EU Joint Programme – Neurodegenerative Disease Research; University of Washington; Agence Nationale de la Recherche; Johns Hopkins University; Wellcome Trust; Robarts Research Institute; Eberhard Karls Universität Tübingen; Cleveland Clinic; London School of Hygiene and Tropical Medicine; Rainwater Charitable Foundation; Alzheimer's Association; Global Brain Health Institute; McGill University; University of Texas Southwestern Medical Center; Association for Frontotemporal Degeneration; Université Laval; University of California, San Diego; Larry L. Hillblom Foundation; Teva Pharmaceutical Industries; Bristol-Myers Squibb; Vanderbilt University; Department of Health and Social Care; Genentech; AstraZeneca; Sunnybrook Research Institute; Northwestern University; Biogen; CurePSP; University of Pennsylvania; National Ataxia Foundation; National Brain Appeal; Universität Ulm; U.S. Department of Defense; University of Oxford; ACADIA Pharmaceuticals","keywords":"Frontotemporal dementia; C9orf72; Biomarker; Clinical trial; Disease; Medicine; Dementia; Oncology; Neuropsychology; Internal medicine; Bioinformatics; Psychology; Psychiatry; Cognition; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001858079,0.0001562743,0.0006859628,0.0002819592,0.00006108214,0.000002531679,0.0001492116,0.0002390943,0.002006095],"category_scores_gemma":[0.0006029281,0.0001102327,0.00004993926,0.0005941807,0.0004253869,0.00003623788,0.000263285,0.001417086,0.000001761303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000487329,"about_ca_system_score_gemma":0.0001416316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009165606,"about_ca_topic_score_gemma":0.0004442999,"domain_scores_codex":[0.9975107,0.0002704212,0.0005987737,0.0003801703,0.0009422575,0.0002976745],"domain_scores_gemma":[0.9991381,0.0001272718,0.0001379102,0.0002819331,0.0001269153,0.0001878508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001464003,0.0002249745,0.9621987,0.00009078329,0.0001210171,0.0001602336,0.0002588019,5.791625e-7,0.005488076,0.00006739217,0.00896126,0.02096423],"study_design_scores_gemma":[0.007352298,0.001502316,0.965259,0.0001066234,0.00006945857,0.00003354523,0.0002634843,0.0003800376,0.00004353558,0.00008753906,0.02480574,0.00009649625],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702868,0.006236771,0.000009491874,0.02131783,0.0005446353,0.000499475,0.00001473231,0.00002237767,0.001067913],"genre_scores_gemma":[0.996426,0.0002976027,0.0005191404,0.001645233,0.0003905346,0.00003212313,0.00007846455,0.00002216399,0.0005887398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02613922,"threshold_uncertainty_score":0.9989062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05760584679299362,"score_gpt":0.3997864645777072,"score_spread":0.3421806177847136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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