{"id":"W4296690345","doi":"10.1038/s41591-022-01942-9","title":"Temporal order of clinical and biomarker changes in familial frontotemporal dementia","year":2022,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":false,"ca_institutions":"Baycrest Hospital; McGill University; Toronto Rehabilitation Institute; Douglas Mental Health University Institute; Université Laval; University of Toronto; Western University; Sunnybrook Health Science Centre; Health Sciences Centre; Occupational Cancer Research Centre; University Health Network; Montreal Neurological Institute and Hospital; University of British Columbia","funders":"David Geffen School of Medicine, University of California, Los Angeles; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Janssen Pharmaceuticals; National Institute on Aging; University College London; NIHR Cambridge Biomedical Research Centre; Tau Consortium; Brain Research UK; Bayer Vital; National Institute of Neurological Disorders and Stroke; Houston Methodist Research Institute; Ministero della Salute; Faculté de Médecine, Université Laval; Pfizer; Centre National de la Recherche Scientifique; Parkinsonfonden; National Institutes of Health; Università degli Studi di Milano; Buck Institute for Research on Aging; Instituto de Salud Carlos III; UK Dementia Research Institute; Sahlgrenska Akademin; Institut National de la Santé et de la Recherche Médicale; H. Lundbeck A/S; Sorbonne Université; Universiteit Antwerpen; Medical Research Council; Vetenskapsrådet; TauRx Pharmaceuticals; Università degli Studi di Brescia; Eli Lilly and Company; Universidade de Lisboa; Göteborgs Universitet; Universidade de Coimbra; Deutsches Zentrum für Neurodegenerative Erkrankungen; Universitat de Barcelona; Université de Lille; Karolinska Institutet; FONDATION ALZHEIMER; Eisai; School of Medicine, Indiana University; Stockholms Läns Landsting; KU Leuven; Cambridge University Hospitals; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; Fondation Brain Canada; Toronto Rehabilitation Institute; Weston Brain Institute; Deutsche Forschungsgemeinschaft; University of North Carolina at Chapel Hill; Wolfson Foundation; University of Toronto; Imperial College London; University of Cambridge; National Institute for Health and Care Research; Puma Biotechnology; University of California, San Francisco; Canadian Institutes of Health Research; Alzheimer's Society; Novartis; Ionis Pharmaceuticals; Università degli Studi di Firenze; University of California, Los Angeles; Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta; University Health Network; EU Joint Programme – Neurodegenerative Disease Research; University of Washington; Agence Nationale de la Recherche; Johns Hopkins University; Wellcome Trust; Robarts Research Institute; Eberhard Karls Universität Tübingen; Cleveland Clinic; London School of Hygiene and Tropical Medicine; Rainwater Charitable Foundation; Alzheimer's Association; Global Brain Health Institute; McGill University; University of Texas Southwestern Medical Center; Association for Frontotemporal Degeneration; Université Laval; University of California, San Diego; Larry L. Hillblom Foundation; Teva Pharmaceutical Industries; Bristol-Myers Squibb; Vanderbilt University; Department of Health and Social Care; Genentech; AstraZeneca; Sunnybrook Research Institute; Northwestern University; Biogen; CurePSP; University of Pennsylvania; National Ataxia Foundation; National Brain Appeal; Universität Ulm; U.S. Department of Defense; University of Oxford; ACADIA Pharmaceuticals","keywords":"Frontotemporal dementia; C9orf72; Biomarker; Clinical trial; Disease; Medicine; Dementia; Oncology; Neuropsychology; Internal medicine; Bioinformatics; Psychology; Psychiatry; Cognition; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001074087,0.0002655828,0.0003231193,0.001775824,0.0004909144,0.0008297959,0.0001785326,0.0005739321,0.002106959],"category_scores_gemma":[0.003787161,0.0001979542,0.0003328571,0.000806427,0.0003004181,0.000660282,0.0004137835,0.0005353143,0.0003251812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004217915,"about_ca_system_score_gemma":0.0003969106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004168179,"about_ca_topic_score_gemma":0.005937049,"domain_scores_codex":[0.999655,0.00008337967,0.00005495604,0.00006766532,0.00005864809,0.00008040905],"domain_scores_gemma":[0.9972313,0.0009082443,0.0009411501,0.0001460134,0.0005042031,0.000269102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005031454,0.00009645804,0.9644169,0.00005925347,0.0001614155,0.00187567,0.0002676101,0.0004086556,0.0107332,0.0007801182,0.001014932,0.01515424],"study_design_scores_gemma":[0.00001485804,0.0002227785,0.9959661,0.00001518841,0.00004429775,0.001600944,0.0001665151,0.0003678022,0.0006351102,0.0004470843,0.0005082985,0.00001109011],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924431,0.001627997,0.0007660427,0.0002658028,0.00004958428,0.00001947926,0.001166248,0.00003687628,0.003624752],"genre_scores_gemma":[0.9980249,0.0002874093,0.000312473,0.00007016124,0.00003744235,0.00001253815,0.000669535,0.000008057749,0.0005773913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004168179,"threshold_uncertainty_score":0.008287847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05760584679299362,"score_gpt":0.3997864645777072,"score_spread":0.3421806177847136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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