{"id":"W4296696831","doi":"10.1136/ard-2022-222259","title":"Risk of major adverse cardiovascular events with tofacitinib versus tumour necrosis factor inhibitors in patients with rheumatoid arthritis with or without a history of atherosclerotic cardiovascular disease: a post hoc analysis from ORAL Surveillance","year":2022,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":204,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Manchester Biomedical Research Centre; St. Jude Medical; Genentech; Idorsia Pharmaceuticals; Assistance publique-Hôpitaux de Paris; Regado Biosciences; Medicines Company; Acceleron; AstraZeneca; Amarin Corporation; Ironwood Pharmaceuticals, Incorporated; National Institutes of Health; Regeneron Pharmaceuticals; University of North Carolina at Chapel Hill; Brigham and Women's Hospital; Boston VA Research Institute; Boston Scientific Corporation; Duke Clinical Research Institute; Eisai; Cytokinetics; Bristol-Myers Squibb; Cleveland Clinic; Belvoir Media Group; Novo Nordisk; MyoKardia; Daiichi Sankyo Europe; Gilead Sciences; HLS Therapeutics; Gedeon Richter; GlaxoSmithKline; National Institute for Health and Care Research; CSL Behring; Eli Lilly and Company; Amgen; Moderna; Pfizer; Sanofi; American Heart Association","keywords":"Medicine; Tofacitinib; Rheumatoid arthritis; Disease; Post-hoc analysis; Internal medicine; Adverse effect; Risk factor; Tumor necrosis factor alpha; Arthritis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004823599,0.0004460081,0.002138283,0.0004247341,0.0001386879,0.00001112322,0.0004436544,0.00004246042,0.0003694177],"category_scores_gemma":[0.0005245064,0.000276338,0.001425937,0.001153993,0.0005824379,0.0002233212,0.000165515,0.000256501,0.000001395827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001662303,"about_ca_system_score_gemma":0.0008921785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005646498,"about_ca_topic_score_gemma":0.0006794411,"domain_scores_codex":[0.9943628,0.000938403,0.0008287738,0.0005893135,0.002774218,0.000506532],"domain_scores_gemma":[0.9964841,0.0003069332,0.0007103735,0.001536089,0.0005896179,0.0003728893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03052699,0.001314635,0.9287204,0.0002809757,0.02659898,0.00002428877,0.001245221,0.006062229,0.00000586651,0.000001986972,0.00004471115,0.005173745],"study_design_scores_gemma":[0.01908282,0.002531007,0.973373,0.002091948,0.0009902082,0.00000281042,0.00115756,0.0002020953,0.00005052803,0.00001420928,0.0001402105,0.0003636097],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685597,0.02554663,0.00002444635,0.00004200873,0.00009335853,0.001484476,0.004209428,0.00003053168,0.000009401001],"genre_scores_gemma":[0.9932861,0.006039343,0.00009509745,0.00001616006,0.00000676083,0.000225542,0.000236779,0.00007376906,0.00002039267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04465263,"threshold_uncertainty_score":0.9999689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861963224089894,"score_gpt":0.2328494525307303,"score_spread":0.2142298202898314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}