{"id":"W4296703009","doi":"10.1084/jem.20212117","title":"Viral proteases activate the CARD8 inflammasome in the human cardiovascular system","year":2022,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Medical Research Council; Nanyang Technological University; National Research Foundation Singapore","keywords":"Inflammasome; Innate immune system; Biology; Proteases; Cell biology; Immunity; Pyroptosis; Coxsackievirus; Endothelium; Virology; Proteasome; Inflammation; Immune system; Immunology; Virus; Enterovirus; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00187545,0.0001305532,0.0002166145,0.0000453748,0.0004118543,0.000008799311,0.0006971721,0.00002693494,0.00002942986],"category_scores_gemma":[0.00003426812,0.00005745857,0.00019466,0.0001133722,0.0001921555,0.000007123883,0.0001664408,0.000325728,9.213685e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005559111,"about_ca_system_score_gemma":0.000040896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001222622,"about_ca_topic_score_gemma":0.000002445283,"domain_scores_codex":[0.9981554,0.0007244082,0.0003533952,0.00009097721,0.0004975073,0.0001783551],"domain_scores_gemma":[0.9992865,0.00002687892,0.0002000694,0.000427627,0.00003588827,0.00002307501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002661172,0.00006271525,0.000275404,0.000009703929,0.0002804763,0.0000322883,0.004536409,0.0004206233,0.9923484,0.0001381067,0.001366466,0.0002632967],"study_design_scores_gemma":[0.00422898,0.003661721,0.003008504,0.00009594663,0.0002297362,0.001528984,0.1899292,0.00001603186,0.7047248,0.00004379561,0.09229226,0.0002400627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974326,0.02311728,0.000009678885,0.0008628317,0.000251084,0.0003837901,0.000001603051,0.000002439768,0.001045301],"genre_scores_gemma":[0.9988961,0.00009395795,0.000002370184,0.0003713389,0.0004972749,0.00005502442,0.000007392302,0.00001367109,0.00006282532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2876236,"threshold_uncertainty_score":0.3167692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01084520849389106,"score_gpt":0.2537548365888803,"score_spread":0.2429096280949892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}