{"id":"W4296705669","doi":"10.1101/2022.09.19.508617","title":"Synaptic scale dopamine disruption in Huntington’s Disease model mice imaged with near infrared catecholamine nanosensors","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemical, Bioengineering, Environmental, and Transport Systems; Camille and Henry Dreyfus Foundation; Philomathia Foundation; U.S. Department of Energy; Gordon and Betty Moore Foundation; Alfred P. Sloan Foundation; National Institute on Drug Abuse; Office of Science; U.S. Department of Agriculture; National Institutes of Health; National Science Foundation","keywords":"Dopamine; Dopaminergic; Neuroscience; Striatum; Autoreceptor; Dopamine transporter; Rotigotine; Catecholamine; Endocrinology; Internal medicine; Chemistry; Psychology; Biology; Medicine; Parkinson's disease; Serotonin; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001429595,0.0003065416,0.0002174237,0.0005008447,0.0001392691,0.0002497461,0.0002397269,0.0004405032,0.001318795],"category_scores_gemma":[0.00006852466,0.0002382419,0.0003079115,0.0001447098,0.0002585506,0.000217889,0.0002291324,0.0007771475,0.0002562125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003285059,"about_ca_system_score_gemma":0.00009494233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007681791,"about_ca_topic_score_gemma":0.001553769,"domain_scores_codex":[0.9998646,0.000007428048,0.00001215902,0.00004849704,0.00004392614,0.00002332779],"domain_scores_gemma":[0.9998184,0.00002179903,0.00007392423,0.00001373804,0.00002357361,0.00004862187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000275221,0.00001293113,0.000186434,0.00001014052,0.000003569525,0.00002625248,0.000009728726,0.00003621724,0.9992599,0.00002797421,0.0000183928,0.0003809372],"study_design_scores_gemma":[0.00001030033,0.0002087813,0.01435949,0.000006872647,0.0000171859,0.0003044317,0.00003891867,0.002631373,0.9815838,0.00006405477,0.0007655323,0.000009273167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852102,0.0005407567,0.01121832,0.0001047749,0.00003704685,0.00004116786,0.001208115,0.0002813347,0.001358348],"genre_scores_gemma":[0.9742867,0.0005896525,0.01699059,0.0001105309,0.00001035705,0.0001521333,0.0009518167,0.00008944589,0.006818701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001318795,"threshold_uncertainty_score":0.004411757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01525538775654521,"score_gpt":0.2283006085251896,"score_spread":0.2130452207686444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}