{"id":"W4296744927","doi":"10.3389/fmolb.2022.942406","title":"Truncated lubricin glycans in osteoarthritis stimulate the synoviocyte secretion of VEGFA, IL-8, and MIP-1α: Interplay between O-linked glycosylation and inflammatory cytokines","year":2022,"lang":"en","type":"article","venue":"Frontiers in Molecular Biosciences","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"National Institutes of Health; Vetenskapsrådet; Göteborgs Universitet; AFA Försäkring; Petrus och Augusta Hedlunds Stiftelse; Västra Götalandsregionen","keywords":"Secretion; Glycan; Glycosylation; Inflammation; Proinflammatory cytokine; Immunology; Osteoarthritis; Chemistry; Interleukin; Cell biology; Medicine; Biology; Glycoprotein; Cytokine; Biochemistry; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001948616,0.0002755398,0.0002222241,0.0002078615,0.00007674452,0.0002460648,0.00006439079,0.0002319722,0.0007079503],"category_scores_gemma":[0.0002344626,0.0001179343,0.0002419632,0.0001271393,0.0001692081,0.0001309526,0.0001474003,0.0002740183,0.00008398915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001590025,"about_ca_system_score_gemma":0.0001235817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003945147,"about_ca_topic_score_gemma":0.0004551584,"domain_scores_codex":[0.9998971,0.00002944324,0.00001273129,0.00001403758,0.00002278874,0.00002390226],"domain_scores_gemma":[0.9999044,0.00001473128,0.00003881876,0.000005409205,0.000008480182,0.00002818652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001352958,0.00004372907,0.00476632,0.00007889939,0.00001753282,0.0001562357,0.00005321906,0.00006110424,0.9904417,0.00003158801,0.00002468867,0.002972182],"study_design_scores_gemma":[0.0002176517,0.004476474,0.2846717,0.0000420677,0.0001658346,0.002456623,0.0003829871,0.002211452,0.7026764,0.0003274557,0.002351669,0.00001967969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980478,0.001416915,0.0003024315,0.00002871407,0.000006052584,0.000007210828,0.00005417051,0.00000607018,0.0001306856],"genre_scores_gemma":[0.9988464,0.0004750672,0.0003272608,0.00001973688,0.000006473915,0.000008710708,0.00007618203,0.000001264926,0.0002390189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007079503,"threshold_uncertainty_score":0.002368331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006372636692420098,"score_gpt":0.23841087397324,"score_spread":0.2320382372808199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}