{"id":"W4296764616","doi":"10.3390/v14092026","title":"Coxsackievirus Protease 2A Targets Host Protease ATG4A to Impair Autophagy","year":2022,"lang":"en","type":"article","venue":"Viruses","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Faculty of Medicine, University of British Columbia; Natural Sciences and Engineering Research Council of Canada; St. Paul's Foundation","keywords":"Autophagy; Protease; Coxsackievirus; Cell biology; Biology; Proteases; Gene silencing; Cleavage (geology); Cysteine protease; Virology; Virus; Biochemistry; Enzyme; Gene; Apoptosis; Enterovirus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002617595,0.000345757,0.0003133098,0.0001918708,0.0001809353,0.0004178703,0.0001573627,0.0003772597,0.001080041],"category_scores_gemma":[0.0001881299,0.0001240146,0.000407381,0.000129851,0.0002270691,0.0002307255,0.0001732798,0.0005770736,0.0003103447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003792842,"about_ca_system_score_gemma":0.0003646782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005316865,"about_ca_topic_score_gemma":0.0007975826,"domain_scores_codex":[0.9998261,0.00003656289,0.00002048056,0.00002732137,0.00004029931,0.00004916622],"domain_scores_gemma":[0.9999244,0.00001536109,0.00002522023,0.00001049753,0.00001067454,0.00001371667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001907217,0.00004159114,0.0004439726,0.00006718961,0.00001809127,0.00009656112,0.00001196634,0.0001022689,0.9970388,0.0002625171,0.0001258851,0.001600447],"study_design_scores_gemma":[0.00002944327,0.0002467351,0.00463111,0.00001118039,0.00002057982,0.0006904135,0.00002851104,0.001713299,0.9891317,0.0001357912,0.003355442,0.000005720798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874448,0.004735609,0.004857692,0.0002637815,0.00009370699,0.00005006799,0.0003774483,0.00007528959,0.002101586],"genre_scores_gemma":[0.9943983,0.00143454,0.002301682,0.0000912847,0.00001098698,0.00002698679,0.0003237731,0.00001323384,0.001399087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001080041,"threshold_uncertainty_score":0.003613055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02625979012690239,"score_gpt":0.3085432128560583,"score_spread":0.2822834227291559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}