{"id":"W4296764616","doi":"10.3390/v14092026","title":"Coxsackievirus Protease 2A Targets Host Protease ATG4A to Impair Autophagy","year":2022,"lang":"en","type":"article","venue":"Viruses","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Faculty of Medicine, University of British Columbia; Natural Sciences and Engineering Research Council of Canada; St. Paul's Foundation","keywords":"Autophagy; Protease; Coxsackievirus; Cell biology; Biology; Proteases; Gene silencing; Cleavage (geology); Cysteine protease; Virology; Virus; Biochemistry; Enzyme; Gene; Apoptosis; Enterovirus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002917187,0.000318384,0.0004271425,0.0002287316,0.0004440661,0.00003606631,0.0002844715,0.0000642583,0.006089816],"category_scores_gemma":[0.0001681442,0.0002913667,0.0002054676,0.0005031474,0.00007366866,0.0001465793,0.0002504359,0.0003695581,0.0009003198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000206624,"about_ca_system_score_gemma":0.0004500404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002380118,"about_ca_topic_score_gemma":0.00000300326,"domain_scores_codex":[0.9976995,0.0001685367,0.0003757019,0.0005451374,0.0006617466,0.0005493491],"domain_scores_gemma":[0.9983709,0.00004893278,0.0001192484,0.0007289212,0.00008100445,0.0006509465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01684464,0.01006252,0.0362495,0.0008229458,0.001417622,0.009329361,0.004642233,0.000363913,0.7160674,0.003610606,0.162527,0.03806225],"study_design_scores_gemma":[0.003811273,0.002431775,0.03325684,0.00007989151,0.0001722504,0.00009686604,0.000294522,0.0001417494,0.2923982,0.0003937926,0.666286,0.0006369067],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887733,0.003733251,0.00009674616,0.001234043,0.0003875804,0.003629609,0.0003729651,0.000519458,0.001253016],"genre_scores_gemma":[0.9712691,0.00004834226,0.000507296,0.0231339,0.0004133149,0.002379131,0.00004986164,0.00009536458,0.002103639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.503759,"threshold_uncertainty_score":0.9999539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02625979012690239,"score_gpt":0.3085432128560583,"score_spread":0.2822834227291559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}