{"id":"W4296787874","doi":"10.15252/embr.202254910","title":"Functional platelet‐derived mitochondria induce the release of human neutrophil microvesicles","year":2022,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vitalité Health Network; Atlantic Cancer Research Institute; Dr. Georges-L.-Dumont University Hospital Centre; Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; Beatrice Hunter Cancer Research Institute; New Brunswick Innovation Foundation; Canadian Institutes of Health Research; Leukemia and Lymphoma Society of Canada; Fondation de la recherche en santé du Nouveau-Brunswick","keywords":"Microvesicles; Cell biology; Inflammation; Neutrophil extracellular traps; Extracellular; Biology; Mitochondrion; Transcriptome; Proinflammatory cytokine; Immune system; Microvesicle; Immunology; Gene expression; Biochemistry; microRNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003238085,0.0002107011,0.0003186926,0.0001080396,0.0008706006,0.00001221864,0.0002295844,0.00009773122,0.003318925],"category_scores_gemma":[0.00003065524,0.0001634551,0.0001729353,0.00021571,0.0002212334,0.00007390861,0.0003113039,0.0005500636,0.00005813406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005387118,"about_ca_system_score_gemma":0.0001063219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001162415,"about_ca_topic_score_gemma":0.000007475529,"domain_scores_codex":[0.9982337,0.0003408577,0.0005601927,0.000440622,0.000111072,0.0003135159],"domain_scores_gemma":[0.9987287,0.00008551231,0.0004726506,0.00060326,0.00008276889,0.0000271146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001039384,0.0001715767,0.0001860466,0.00000698077,0.0001508138,0.0002900092,0.0002530148,0.00003720035,0.9840093,0.001632108,0.01243662,0.0007224285],"study_design_scores_gemma":[0.0005724935,0.0002864647,0.005796928,0.000008399181,0.00004256807,0.001384946,0.0004465256,2.68844e-7,0.9511363,0.001980818,0.03815667,0.0001876162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955181,0.0008808753,0.0000310274,0.0005700216,0.001558194,0.0003472106,0.00003239711,0.00005955892,0.001002547],"genre_scores_gemma":[0.9959929,0.000009536908,0.00003208744,0.0005125942,0.00008880261,0.0001078688,0.00023597,0.00002907262,0.002991189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03287296,"threshold_uncertainty_score":0.9975922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01895027354823425,"score_gpt":0.227022753452372,"score_spread":0.2080724799041378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}