{"id":"W4296792091","doi":"10.1093/genetics/iyac144","title":"Intrinsic base substitution patterns in diverse species reveal links to cancer and metabolism","year":2022,"lang":"en","type":"article","venue":"Genetics","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; University of Ottawa","keywords":"Biology; Genetics; Mutagenesis; Saccharomyces cerevisiae; Mutation; Gene; Computational biology; Nucleotide; Evolutionary biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001169153,0.0001075336,0.0001013677,0.00007591046,0.0001035333,0.00001370316,0.0001230902,0.00007799755,0.00007632624],"category_scores_gemma":[0.00001948738,0.0001226699,0.0000304762,0.0001287072,0.00003854504,0.0000013778,0.0003658106,0.0001479529,0.000003405575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003637273,"about_ca_system_score_gemma":0.00006266157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000693789,"about_ca_topic_score_gemma":0.001190602,"domain_scores_codex":[0.999187,0.00005333914,0.0001499194,0.0002803137,0.0001326965,0.0001967237],"domain_scores_gemma":[0.9996259,0.000003615438,0.00003524753,0.0002068148,0.00003922203,0.00008925826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002221068,0.0002504616,0.4053561,0.00005797096,0.00008569148,0.00003745785,0.001054048,0.08451556,0.469209,0.001035579,0.008775105,0.02940089],"study_design_scores_gemma":[0.001253286,0.0002079265,0.7132386,0.000009186821,0.00004006066,0.00002234088,0.0006158786,0.00136613,0.014242,0.0001027864,0.2684567,0.0004451041],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958674,0.001673572,0.001215552,0.0004728347,0.0003014061,0.000177948,0.0001909398,0.000006762994,0.00009359669],"genre_scores_gemma":[0.9959025,0.001045745,0.0008070769,0.0009562527,0.000176927,0.00004938244,0.0001062155,0.00001257332,0.0009432611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.454967,"threshold_uncertainty_score":0.5002334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277646593226441,"score_gpt":0.2451896132279489,"score_spread":0.2324131472956845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}