{"id":"W4296793867","doi":"10.1186/s40478-022-01438-0","title":"Letter to the editor on a paper by Kaivola et al. (2020): carriership of two copies of C9orf72 hexanucleotide repeat intermediate-length alleles is not associated with amyotrophic lateral sclerosis or frontotemporal dementia","year":2022,"lang":"en","type":"letter","venue":"Acta Neuropathologica Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"","keywords":"C9orf72; Amyotrophic lateral sclerosis; Neurology; Medicine; Genetics; Neuroscience; Allele; Psychology; Psychiatry; Biology; Trinucleotide repeat expansion; Pathology; Gene; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000970964,0.0007162419,0.00129362,0.0002607323,0.0005166375,0.0001084509,0.003200631,0.0003925512,0.00120336],"category_scores_gemma":[0.001366595,0.0004392708,0.0003747369,0.0006592438,0.001093897,0.0002012009,0.002226969,0.004828315,0.00002206258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002559069,"about_ca_system_score_gemma":0.0002381765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004070538,"about_ca_topic_score_gemma":0.0002183588,"domain_scores_codex":[0.9915372,0.003751562,0.001204912,0.000981043,0.001717264,0.0008080925],"domain_scores_gemma":[0.9917428,0.001813026,0.0009901809,0.00473761,0.0005182622,0.0001981326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000899735,0.0003888646,0.003932037,0.00005333714,0.0004702958,0.0001565598,0.0009263883,0.000006387264,0.01634247,0.00000345031,0.9767035,0.0001169922],"study_design_scores_gemma":[0.001867774,0.00395592,0.08475716,0.0006180668,0.0005043143,0.00003344454,0.0000834032,0.00003349461,0.0002359974,0.000007631401,0.9073735,0.0005292511],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.253506,0.0002333955,0.000003907806,0.7423885,0.0003894086,0.001551055,0.001582157,0.0001155834,0.0002299925],"genre_scores_gemma":[0.5238263,0.001241659,0.0002855136,0.47159,0.0005198283,0.0004183154,0.001099114,0.0001210022,0.0008982621],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.2707985,"threshold_uncertainty_score":0.9998059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06016373794654001,"score_gpt":0.3025630229204742,"score_spread":0.2423992849739342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}