{"id":"W4296799947","doi":"10.1001/jama.2022.15632","title":"Effect of Roflumilast Cream vs Vehicle Cream on Chronic Plaque Psoriasis","year":2022,"lang":"en","type":"article","venue":"JAMA","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; SKiN Health; Queen's University","funders":"Amgen","keywords":"Medicine; Roflumilast; Psoriasis; Discontinuation; Randomized controlled trial; Clinical trial; Randomization; Intertriginous; Clinical endpoint; Internal medicine; Dermatology; COPD; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001258946,0.0005968087,0.001789258,0.0003480306,0.0003118773,0.0005500045,0.000511331,0.0008900032,0.004572905],"category_scores_gemma":[0.001621985,0.0003535281,0.0007505232,0.0002467755,0.0005046357,0.0007042385,0.0002573698,0.00152206,0.000681817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003136012,"about_ca_system_score_gemma":0.0005246513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005143539,"about_ca_topic_score_gemma":0.0009666805,"domain_scores_codex":[0.9994443,0.0002829411,0.00004225573,0.00007519218,0.00006609249,0.00008916087],"domain_scores_gemma":[0.9990472,0.0004832576,0.0001610643,0.00004195622,0.00004184015,0.0002247642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7784782,0.02626758,0.001700678,0.001683429,0.000728228,0.0001633434,0.0001534318,0.0007381117,0.06707408,0.0001110089,0.001601092,0.1213008],"study_design_scores_gemma":[0.3339694,0.6315675,0.01550532,0.0001568403,0.0009212232,0.0002695498,0.00007934513,0.001521556,0.01391168,0.0002074292,0.001850842,0.0000393533],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991927,0.005648488,0.000145345,0.0002513449,0.000236404,0.0003060389,0.0001362967,0.00005595031,0.001293103],"genre_scores_gemma":[0.995692,0.002238089,0.0003964952,0.0001969756,0.0002457112,0.0002945192,0.0001315418,0.00001068924,0.0007938979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004572905,"threshold_uncertainty_score":0.01529789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007924494824205035,"score_gpt":0.2310752618001705,"score_spread":0.2231507669759655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}