{"id":"W4296804188","doi":"10.1002/ctm2.1056","title":"Sphingosine 1‐phosphate lyase facilitates cancer progression through converting sphingolipids to glycerophospholipids","year":2022,"lang":"en","type":"article","venue":"Clinical and Translational Medicine","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"Japan Society for the Promotion of Science; Japan Agency for Medical Research and Development","keywords":"Sphingolipid; Sphingosine; Colorectal cancer; Sphingosine-1-phosphate; Cancer; Cancer research; Cancer cell; Chemistry; Biology; Receptor; Biochemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008503838,0.0002160198,0.0003710447,0.00004128922,0.0003896542,0.00001219934,0.0001882136,0.00008869088,0.0004648266],"category_scores_gemma":[0.0002854137,0.0001769577,0.0001054011,0.0002147832,0.0002771226,0.00001166746,0.0001405055,0.0002736764,0.000004174605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005547556,"about_ca_system_score_gemma":0.00008730559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001440776,"about_ca_topic_score_gemma":0.00001052045,"domain_scores_codex":[0.9979074,0.0001255624,0.0006830484,0.0005898015,0.0003930264,0.000301184],"domain_scores_gemma":[0.9992115,0.0001272135,0.0001165861,0.000208292,0.00009650028,0.0002399174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007439202,0.0009006949,0.4367293,0.0004015762,0.0006232183,0.00004696508,0.005999851,0.004167119,0.3220066,0.005590629,0.01297373,0.2031212],"study_design_scores_gemma":[0.01027691,0.002371079,0.07879973,0.0002331191,0.0002268549,0.00004624072,0.0006898477,0.001189067,0.01724166,0.002612556,0.8854446,0.0008683382],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744211,0.01256114,0.001946279,0.009042991,0.001352164,0.0003529518,0.00008657132,0.00003118776,0.0002056489],"genre_scores_gemma":[0.9906586,0.0008632151,0.001230329,0.00481215,0.001807524,0.0001163311,0.0001918205,0.00002741928,0.0002925802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8724709,"threshold_uncertainty_score":0.7216124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0414749211608464,"score_gpt":0.3750701590109869,"score_spread":0.3335952378501406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}