{"id":"W4296804188","doi":"10.1002/ctm2.1056","title":"Sphingosine 1‐phosphate lyase facilitates cancer progression through converting sphingolipids to glycerophospholipids","year":2022,"lang":"en","type":"article","venue":"Clinical and Translational Medicine","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"Japan Society for the Promotion of Science; Japan Agency for Medical Research and Development","keywords":"Sphingolipid; Sphingosine; Colorectal cancer; Sphingosine-1-phosphate; Cancer; Cancer research; Cancer cell; Chemistry; Biology; Receptor; Biochemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007246459,0.0002377522,0.0001287785,0.0001953151,0.0001158004,0.000229211,0.00008817662,0.0001706972,0.001370167],"category_scores_gemma":[0.00008841717,0.00008011649,0.0001789431,0.0001579861,0.0001766463,0.0001376683,0.0001709807,0.0003083113,0.0003170635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000196879,"about_ca_system_score_gemma":0.0001848179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004735477,"about_ca_topic_score_gemma":0.0005427118,"domain_scores_codex":[0.9999344,0.000009947121,0.000004544995,0.00001486893,0.00001482193,0.00002138902],"domain_scores_gemma":[0.9999384,0.000006734501,0.00002323245,0.00000471728,0.000008155542,0.00001885581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002574081,0.00002386101,0.001126027,0.00007095173,0.000006000599,0.00009229172,0.00001466171,0.0000393888,0.9956074,0.00006478763,0.00009845619,0.002598584],"study_design_scores_gemma":[0.00002971814,0.0006143515,0.02794202,0.00001718852,0.00004968373,0.0006504668,0.00009234447,0.0008061901,0.9638676,0.000103761,0.005819851,0.000006761631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909973,0.005423501,0.001375129,0.0002177605,0.00002516165,0.00002374961,0.0003032199,0.0001002725,0.001533829],"genre_scores_gemma":[0.9951581,0.002440432,0.0006971949,0.00003671884,0.000008937224,0.0000168245,0.0002145478,0.000005191623,0.001422078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001370167,"threshold_uncertainty_score":0.004583657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0414749211608464,"score_gpt":0.3750701590109869,"score_spread":0.3335952378501406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}