{"id":"W4296809949","doi":"10.1002/alz.12799","title":"Complement dysregulation and Alzheimer's disease in Down syndrome","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; University College London; King's College London; Newcastle University; Alzheimer's Society; UK Dementia Research Institute; Fondation Jérôme Lejeune; EU Joint Programme – Neurodegenerative Disease Research","keywords":"Disease; Complement (music); Alzheimer's disease; Neuroscience; Complement system; Medicine; Psychology; Immunology; Biology; Genetics; Pathology; Immune system; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003590901,0.0006705278,0.0003536214,0.0008278235,0.0003605567,0.0006333393,0.0002409597,0.0003959874,0.002456012],"category_scores_gemma":[0.0009046597,0.0001329779,0.0003087231,0.0008236811,0.0003260271,0.0002870029,0.0004150276,0.0003878973,0.0001810921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004804502,"about_ca_system_score_gemma":0.0003170681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005582511,"about_ca_topic_score_gemma":0.002856485,"domain_scores_codex":[0.9998098,0.00003559505,0.00002781274,0.00006192721,0.00004308008,0.00002196104],"domain_scores_gemma":[0.9996738,0.00006589624,0.0001600211,0.00001032254,0.00005573464,0.00003417097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001358978,0.00006545356,0.9469571,0.000424804,0.000427397,0.003522127,0.0003384815,0.0002089468,0.009772268,0.0005100405,0.001193982,0.03522046],"study_design_scores_gemma":[0.00002717081,0.0002067919,0.983885,0.000278493,0.0003709189,0.009288143,0.0002238794,0.0002994394,0.001889877,0.0008069495,0.002705774,0.00001752001],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815112,0.01433951,0.0004310884,0.0004594701,0.000053723,0.00001798332,0.001178661,0.00002074745,0.001987689],"genre_scores_gemma":[0.9933044,0.004573642,0.0006694794,0.0001388755,0.00004175115,0.00001399955,0.0006468021,0.000003804933,0.0006071857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005582511,"threshold_uncertainty_score":0.01110005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03247893057673005,"score_gpt":0.2943482676419804,"score_spread":0.2618693370652503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}