{"id":"W4296809949","doi":"10.1002/alz.12799","title":"Complement dysregulation and Alzheimer's disease in Down syndrome","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; University College London; King's College London; Newcastle University; Alzheimer's Society; UK Dementia Research Institute; Fondation Jérôme Lejeune; EU Joint Programme – Neurodegenerative Disease Research","keywords":"Disease; Complement (music); Alzheimer's disease; Neuroscience; Complement system; Medicine; Psychology; Immunology; Biology; Genetics; Pathology; Immune system; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002672622,0.0001826965,0.0002632096,0.0002122304,0.0001749508,0.00001735673,0.0001155756,0.00002670525,0.00293879],"category_scores_gemma":[0.00001180213,0.0002036769,0.00006649292,0.0002161051,0.00009010398,0.00007851079,0.0004911567,0.0001670567,0.00003364056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002141383,"about_ca_system_score_gemma":0.00007318189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009249501,"about_ca_topic_score_gemma":0.00002314264,"domain_scores_codex":[0.9983313,0.0001478477,0.0003778989,0.0004402516,0.0003665995,0.0003360902],"domain_scores_gemma":[0.9991877,0.00003807032,0.00009256526,0.0004071464,0.00002686563,0.0002476674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001136488,0.001292567,0.9411542,0.00003989421,0.009584804,0.002965142,0.000921148,0.0006835262,0.0009107763,0.001347613,0.005182717,0.03478117],"study_design_scores_gemma":[0.002162353,0.0002918825,0.9735819,0.00001664453,0.0122388,0.0002140929,0.0001369727,0.00172013,0.00007325456,0.0004275727,0.00890371,0.0002327569],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9284289,0.06721254,0.00002707437,0.002325437,0.0003414923,0.001082144,0.00008525362,0.00007562018,0.0004215189],"genre_scores_gemma":[0.9977308,0.00002405048,0.0006010885,0.0009111009,0.00003557746,0.0003283057,0.0003292513,0.00003178398,0.000008074035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06930184,"threshold_uncertainty_score":0.9979727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03247893057673005,"score_gpt":0.2943482676419804,"score_spread":0.2618693370652503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}