{"id":"W4296816530","doi":"10.1002/mds.29190","title":"Putaminal Recombinant Glucocerebrosidase Delivery with Magnetic Resonance<scp>–</scp>Guided Focused Ultrasound in Parkinson's Disease: A Phase I Study","year":2022,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto; University Health Network; Health Sciences Centre; Toronto Rehabilitation Institute; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Focused Ultrasound Foundation","keywords":"Medicine; Magnetic resonance imaging; Parkinson's disease; Essential tremor; Movement disorders; Glucocerebrosidase; Positron emission tomography; Adverse effect; Putamen; Internal medicine; Pharmacology; Nuclear medicine; Disease; Radiology; Physical medicine and rehabilitation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001055185,0.001511376,0.00141045,0.0004019233,0.0002667148,0.0007889317,0.001135736,0.001456793,0.001086738],"category_scores_gemma":[0.0003979141,0.0003795973,0.0008782792,0.0003823561,0.001148965,0.0007520101,0.0002681401,0.002032831,0.0003144317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008220416,"about_ca_system_score_gemma":0.0009390317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001262167,"about_ca_topic_score_gemma":0.001474399,"domain_scores_codex":[0.9996791,0.0001148925,0.00002134122,0.00006420547,0.00004325129,0.00007719058],"domain_scores_gemma":[0.9996662,0.00005417423,0.00009365619,0.00003991046,0.00002989053,0.0001161542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2015842,0.1185029,0.002595979,0.001745411,0.001340675,0.0006444119,0.0008826253,0.003848034,0.5335929,0.0004415175,0.002376241,0.1324452],"study_design_scores_gemma":[0.1145561,0.8114941,0.005315676,0.00005407633,0.0005744879,0.0006140805,0.00008202017,0.001806105,0.06337552,0.0001281898,0.001956017,0.00004364966],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995016,0.001842748,0.001319224,0.000149337,0.00004641378,0.0009271737,0.00018208,0.00007023213,0.0004468244],"genre_scores_gemma":[0.9921283,0.002149137,0.002625882,0.0003114689,0.00007547021,0.001158026,0.0007068147,0.0000295021,0.0008154122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001511376,"threshold_uncertainty_score":0.005964339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007717332063946338,"score_gpt":0.2099382578664339,"score_spread":0.2022209258024876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}