{"id":"W4296843975","doi":"10.1016/j.euroneuro.2022.07.180","title":"95. GENOME-WIDE ASSOCIATION STUDY OF 14,000 CASES IDENTIFIES FOUR NEW RISK GENES AND IMPLICATES CALCIUM SIGNALING IN TOURETTE SYNDROME AND CHRONIC TIC DISORDERS","year":2022,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Nutrition, Genetics, and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Gene; Genome-wide association study; Tourette syndrome; Association (psychology); Genetics; Genetic association; Biology; Calcium signaling; Bioinformatics; Neuroscience; Medicine; Psychiatry; Signal transduction; Psychology; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001026672,0.0004321626,0.0005951254,0.001675354,0.001078098,0.00101824,0.0008088112,0.001079878,0.008149362],"category_scores_gemma":[0.003411675,0.0003349798,0.0008304145,0.001663176,0.0004077332,0.0004850802,0.000551559,0.0007482041,0.0007233108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003669784,"about_ca_system_score_gemma":0.000513003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01676908,"about_ca_topic_score_gemma":0.01331238,"domain_scores_codex":[0.9990224,0.0001922841,0.00008761205,0.0003101742,0.0001867583,0.0002008432],"domain_scores_gemma":[0.9987514,0.0004024779,0.0002762966,0.0001460924,0.0001551438,0.0002685777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001169116,0.00009698546,0.9775333,0.00005257076,0.0006876243,0.001430632,0.0001396977,0.00009461582,0.005198102,0.0004113712,0.001853298,0.01133272],"study_design_scores_gemma":[0.00007987513,0.00008829465,0.9949139,0.00001511964,0.0004244903,0.001736105,0.0000714828,0.0001621169,0.0004790073,0.0002274624,0.001795441,0.000006706083],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825378,0.0033727,0.001338734,0.0008480087,0.00009870926,0.00003716181,0.005773866,0.0001628068,0.005830216],"genre_scores_gemma":[0.9931115,0.0005543664,0.0005787138,0.0001939436,0.00005359748,0.00002788172,0.002757181,0.00002181118,0.002700899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01676908,"threshold_uncertainty_score":0.03334296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01285425895074866,"score_gpt":0.2647395896716125,"score_spread":0.2518853307208639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}